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Tbio
COG8
Conserved oligomeric Golgi complex subunit 8

Protein Summary
Description
Required for normal Golgi function. This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000648169
  • ENSP00000497669
  • ENSG00000213380

Symbol
  • DOR1
  • CDG2H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
tissue sample
0.73
transcription factor binding site profile
0.73
hub protein
0.67
cellular component
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.86   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.86   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (153)
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999999919
p_ni:  8e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG5
Tbio
Novelty:  0.04017657
p_int:  0.999999866
p_ni:  1.34e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG3
Tbio
Novelty:  0.02746711
p_int:  0.999999658
p_ni:  3.41e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG7
Tbio
Novelty:  0.07137701
p_int:  0.999999509
p_ni:  4.91e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG2
Tbio
Novelty:  0.03109287
p_int:  0.999999482
p_ni:  5.18e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999357305
p_ni:  0.000642694
Score:  0.609
Data Source:  BioPlex,STRINGDB
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.999292278
p_ni:  0.000707721
p_wrong:  1e-9
Score:  0.764
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.995554791
p_ni:  0.004445208
Score:  0.192
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.989154057
p_ni:  0.010741591
p_wrong:  0.000104351
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.978749232
p_ni:  0.019648729
p_wrong:  0.00160204
Score:  0.695
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
2
4
80.6
daytime rest measurement
1
1
1
55.2
telomere length
1
1
1
38.8
apolipoprotein A 1 measurement
1
1
1
35
total cholesterol measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
80.6
daytime rest measurement
1
55.2
telomere length
1
38.8
apolipoprotein A 1 measurement
1
35
total cholesterol measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 8
454199
Mouse
MGI:2142885
97484
Rat
RGD:1307074
291990
Dog
component of oligomeric golgi complex 8
489737
Horse
component of oligomeric golgi complex 8
100067058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 8
Mouse
Rat
Dog
component of oligomeric golgi complex 8
Horse
component of oligomeric golgi complex 8
Publication Statistics
PubMed Score 37.86
PubMed score by year
PubTator Score 7.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title