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Tbio
COG5
Conserved oligomeric Golgi complex subunit 5

Protein Summary
Description
Required for normal Golgi function. The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297135
  • ENSP00000297135
  • ENSG00000164597
  • ENST00000347053
  • ENSP00000334703
  • ENST00000393603
  • ENSP00000377228

Symbol
  • GOLTC1
  • GTC90
  • CDG2I
  • GTC90
  • GOLTC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
microRNA
0.77
virus perturbation
0.76
interacting protein
0.73
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.24   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.24   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (183)
COG3
Tbio
Novelty:  0.02746711
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG7
Tbio
Novelty:  0.07137701
p_int:  0.999999923
p_ni:  7.6e-8
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG1
Tbio
Novelty:  0.0124285
p_int:  0.999999867
p_ni:  1.32e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG8
Tbio
Novelty:  0.02448169
p_int:  0.999999866
p_ni:  1.34e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG2
Tbio
Novelty:  0.03109287
p_int:  0.999999111
p_ni:  8.89e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG4
Tbio
Novelty:  0.03809668
p_int:  0.999998674
p_ni:  0.000001325
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC136
Tbio
Novelty:  0.09279967
p_int:  0.999989259
p_ni:  0.000010741
Data Source:  BioPlex
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
p_int:  0.999564483
p_ni:  0.000435517
Score:  0.315
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.998986403
p_ni:  0.001013597
Score:  0.245
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
9.2
88.6
apolipoprotein A 1 measurement
1
1
1
67.8
high density lipoprotein cholesterol measurement
1
1
1
59.6
5
5
3
1.1
57.7
electrocardiography
1
1
2
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
9.2
88.6
apolipoprotein A 1 measurement
1
67.8
high density lipoprotein cholesterol measurement
1
59.6
3
1.1
57.7
electrocardiography
2
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 5
VGNC:4314
463651
Macaque
component of oligomeric golgi complex 5
699108
Mouse
MGI:2145130
238123
Rat
RGD:1563296
314030
Dog
component of oligomeric golgi complex 5
VGNC:39451
483265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 5
Macaque
component of oligomeric golgi complex 5
Mouse
Rat
Dog
component of oligomeric golgi complex 5
Publication Statistics
PubMed Score 23.24
PubMed score by year
PubTator Score 11.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title