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Tbio
COG3
Conserved oligomeric Golgi complex subunit 3

Protein Summary
Description
Involved in ER-Golgi transport. This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349995
  • ENSP00000258654
  • ENSG00000136152
  • ENST00000617493
  • ENSP00000481332

Symbol
  • SEC34
  • SEC34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
interacting protein
0.86
virus perturbation
0.76
histone modification site profile
0.75
transcription factor binding site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.01   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.01   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (199)
COG5
Tbio
Novelty:  0.04017657
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC18
Tdark
Novelty:  0.61246881
p_int:  0.999999975
p_ni:  1.1e-8
p_wrong:  1.4e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
COG1
Tbio
Novelty:  0.0124285
p_int:  0.9999997
p_ni:  2.99e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG8
Tbio
Novelty:  0.02448169
p_int:  0.999999658
p_ni:  3.41e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG7
Tbio
Novelty:  0.07137701
p_int:  0.999999619
p_ni:  3.8e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG2
Tbio
Novelty:  0.03109287
p_int:  0.999999347
p_ni:  6.53e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG4
Tbio
Novelty:  0.03809668
p_int:  0.999982131
p_ni:  0.000017869
Score:  0.999
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999979804
p_ni:  0.000020195
p_wrong:  1e-9
Score:  0.8
Data Source:  BioPlex,STRINGDB
TBCC
Tbio
Novelty:  0.07928844
p_int:  0.999915017
p_ni:  0.000084955
p_wrong:  2.9e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
1
2
67.7
albuminuria
1
1
0
30.6
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
67.7
albuminuria
0
30.6
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 3
VGNC:5052
452579
Macaque
component of oligomeric golgi complex 3
702375
Mouse
MGI:2450151
338337
Rat
RGD:1304555
361073
Dog
component of oligomeric golgi complex 3
VGNC:39449
485455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 3
Macaque
component of oligomeric golgi complex 3
Mouse
Rat
Dog
component of oligomeric golgi complex 3
Publication Statistics
PubMed Score 37.01
PubMed score by year
PubTator Score 14.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title