Tbio COG3 Conserved oligomeric Golgi complex subunit 3

Protein Summary

Description

Involved in ER-Golgi transport. This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q96JB2
• B2RAW5
• Q5VT70
• Q8IXX4
• Q9BZ92
• COG complex subunit 3

Gene Name

• COG3

Ensembl ID

• ENST00000349995
• ENSP00000258654
• ENSG00000136152
• ENST00000617493
• ENSP00000481332

Symbol

• SEC34
• SEC34

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
interacting protein	0.86
virus perturbation	0.76
histone modification site profile	0.75
transcription factor binding site profile	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.51   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.51   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0