Tbio COG2 Conserved oligomeric Golgi complex subunit 2

Protein Summary

Description

Required for normal Golgi morphology and function. This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q14746
• Q86U99
• COG complex subunit 2

Gene Name

• COG2

Ensembl ID

• ENST00000366668
• ENSP00000355628
• ENSG00000135775
• ENST00000366669
• ENSP00000355629

Symbol

• LDLC
• LDLC
• CDG2Q

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor binding site profile	0.84
transcription factor	0.73
tissue sample	0.68
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.79   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 205   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.79   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0