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Tbio
COCH
Cochlin

Protein Summary
Description
Plays a role in the control of cell shape and motility in the trabecular meshwork. The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding disti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396618
  • ENSP00000379862
  • ENSG00000100473
  • ENST00000475087
  • ENSP00000451528
  • ENST00000643575
  • ENSP00000494838
  • ENST00000644874
  • ENSP00000496360

Symbol
  • COCH5B2
  • DFNA9
  • COCH5B2
  • DFNB110
  • COCH-5B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
gene perturbation
0.91
kinase perturbation
0.81
histone modification site profile
0.78
small molecule perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.47   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.47   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.999546155
p_ni:  0.000453845
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.952906372
p_ni:  0.047093628
Data Source:  BioPlex
IDS
Tbio
Family:  Enzyme
Novelty:  0.00733996
p_int:  0.9369818
p_ni:  0.0630182
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.932837696
p_ni:  0.067162304
Data Source:  BioPlex
VIT
Tbio
Novelty:  0.13376369
p_int:  0.905218581
p_ni:  0.094781419
Score:  0.326
Data Source:  BioPlex,STRINGDB
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.886588982
p_ni:  0.113411018
Data Source:  BioPlex
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.885017462
p_ni:  0.114982538
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.84610457
p_ni:  0.153895431
Data Source:  BioPlex
CD160
Tbio
Novelty:  0.01511748
p_int:  0.84087978
p_ni:  0.15912022
Data Source:  BioPlex
TRAC
Tdark
p_int:  0.832281194
p_ni:  0.167718806
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
94.5
platelet count
1
1
1
52.4
biological sex
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
94.5
platelet count
1
52.4
biological sex
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cochlin
VGNC:12614
452837
Macaque
cochlin
717114
Mouse
MGI:1278313
12810
Dog
cochlin
VGNC:39447
490640
Horse
cochlin
VGNC:16711
100055742
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cochlin
Macaque
cochlin
Mouse
Dog
cochlin
Horse
cochlin
Publication Statistics
PubMed Score 137.47
PubMed score by year
PubTator Score 172.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title