Tbio COBL Protein cordon-bleu

Protein Summary

Description

Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• O75128
• A4D257
• A7E2B0
• B7ZLW9
• B9EGF8
• Q2T9J3
• Q504Y4
• Q86XA7
• Q8N304
• Q8TCM1

Gene Name

• COBL

Ensembl ID

• ENST00000265136
• ENSP00000265136
• ENSG00000106078
• ENST00000395540
• ENSP00000378910
• ENST00000395542
• ENSP00000378912
• ENST00000441453
• ENSP00000399500

Symbol

• KIAA0633

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.89
cellular component	0.79
PubMedID	0.78
transcription factor perturbation	0.74
transcription factor binding site profile	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.17   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.17   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0