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Tbio
COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

Protein Summary
Description
Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly. This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328434
  • ENSP00000354762
  • ENSG00000183978

Symbol
  • CCDC56
  • MITRAC12
  • COX25
  • CCDC56
  • HSPC009
  • MITRAC12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
virus perturbation
0.85
cell type or tissue
0.79
histone modification site profile
0.7
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.79   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.79   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
CMC1
Tdark
Novelty:  5.14727585
p_int:  0.99999894
p_ni:  0.000001031
p_wrong:  2.9e-8
Score:  0.478
Data Source:  BioPlex,STRINGDB
SNX25
Tbio
Novelty:  0.15818269
p_int:  0.99978256
p_ni:  0.000212017
p_wrong:  0.000005423
Data Source:  BioPlex
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
p_int:  0.961979707
p_ni:  0.037397296
p_wrong:  0.000622997
Data Source:  BioPlex
COX14
Tbio
Family:  Enzyme
Novelty:  0.09340462
p_int:  0.949573752
p_ni:  0.000015349
p_wrong:  0.050410899
Score:  0.829
Data Source:  BioPlex,STRINGDB
COX5B
Tbio
Family:  Enzyme
Novelty:  0.01729026
p_int:  0.938884897
p_ni:  0.061115103
Score:  0.483
Data Source:  BioPlex,STRINGDB
P39880
Tbio
Novelty:  0.00415896
p_int:  0.763460207
p_ni:  0.236539793
Data Source:  BioPlex
TACO1
Tbio
Family:  Enzyme
Novelty:  0.10710318
Score:  0.824
Data Source:  STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.785
Data Source:  STRINGDB
COX10
Tbio
Family:  Enzyme
Novelty:  0.0156235
Score:  0.736
Data Source:  STRINGDB
MSS51
Tbio
Novelty:  0.06388791
Score:  0.726
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
4
4
76.6
waist-hip ratio
1
3
3
72.9
waist circumference
1
2
2
43.8
triglyceride measurement
1
1
1
33.1
2
1
1
1.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
76.6
waist-hip ratio
3
72.9
waist circumference
2
43.8
triglyceride measurement
1
33.1
1
1.1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase assembly factor 3
VGNC:9241
741519
Macaque
cytochrome c oxidase assembly factor 3 homolog, mitochondrial
695732
Mouse
MGI:1098757
52469
Rat
RGD:1564337
498000
Dog
coiled-coil domain containing 56
480514
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase assembly factor 3
Macaque
cytochrome c oxidase assembly factor 3 homolog, mitochondrial
Mouse
Rat
Dog
coiled-coil domain containing 56
Publication Statistics
PubMed Score 18.79
PubMed score by year
PubTator Score 9.01
PubTator score by year
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Related Publications
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PMID
Year
Title