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Tbio
COA1
Cytochrome c oxidase assembly factor 1 homolog

Protein Summary
Description
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223336
  • ENSP00000223336
  • ENSG00000106603
  • ENST00000310564
  • ENSP00000312100
  • ENST00000395879
  • ENSP00000379218
  • ENST00000415076
  • ENSP00000400759
  • ENST00000438444
  • ENSP00000395586
  • ENST00000446330
  • ENSP00000416406
  • ENST00000446564
  • ENSP00000413777

Symbol
  • C7orf44
  • MITRAC15
  • C7orf44
  • MITRAC15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
tissue sample
0.69
cellular component
0.68
co-expressed gene
0.57
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.999970654
p_ni:  0.000029266
p_wrong:  8e-8
Data Source:  BioPlex
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.999819702
p_ni:  0.000180291
p_wrong:  6e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
Q6EEV4
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999755924
p_ni:  0.000243755
p_wrong:  3.21e-7
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.999544091
p_ni:  0.000455904
p_wrong:  5e-9
Data Source:  BioPlex
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.999148709
p_ni:  0.000851275
p_wrong:  1.6e-8
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.999062471
p_ni:  0.000937513
p_wrong:  1.6e-8
Data Source:  BioPlex
RNF185
Tbio
Family:  Enzyme
Novelty:  0.23911257
p_int:  0.998591414
p_ni:  0.001408534
p_wrong:  5.2e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.994337742
p_ni:  0.0009812
p_wrong:  0.004681058
Data Source:  BioPlex
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.899373634
p_ni:  0.050701014
p_wrong:  0.049925351
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.846679062
p_ni:  0.07984574
p_wrong:  0.073475198
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
70.2
mean corpuscular volume
1
1
1
62.5
mean corpuscular hemoglobin concentration
1
1
1
51.4
peak insulin response measurement
1
1
1
0.4
pulmonary non-tuberculous mycobacterial infection
1
1
0
1.3
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
70.2
mean corpuscular volume
1
62.5
mean corpuscular hemoglobin concentration
1
51.4
peak insulin response measurement
1
0.4
pulmonary non-tuberculous mycobacterial infection
0
1.3
0.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase assembly factor 1 homolog
VGNC:4312
736211
Macaque
cytochrome C oxidase assembly factor 1 homolog (S. cerevisiae)
701198
Dog
cytochrome c oxidase assembly factor 1 homolog
VGNC:39442
608597
Horse
cytochrome c oxidase assembly factor 1 homolog
VGNC:16705
100064650
Cow
cytochrome c oxidase assembly factor 1 homolog
VGNC:27542
505736
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c oxidase assembly factor 1 homolog
Macaque
cytochrome C oxidase assembly factor 1 homolog (S. cerevisiae)
Dog
cytochrome c oxidase assembly factor 1 homolog
Horse
cytochrome c oxidase assembly factor 1 homolog
Cow
cytochrome c oxidase assembly factor 1 homolog
Publication Statistics
PubMed Score 3.11
PubMed score by year
PubTator Score 5.83
PubTator score by year
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Related Publications
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PMID
Year
Title