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Tbio
CNTRL
Centriolin

Protein Summary
Description
Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238341
  • ENSP00000238341
  • ENSG00000119397
  • ENST00000373850
  • ENSP00000362956
  • ENST00000373855
  • ENSP00000362962
  • ENST00000613863
  • ENSP00000481072

Symbol
  • CEP1
  • CEP110
  • FAN
  • CEP1
  • CEP110
  • bA165P4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
cell line
0.69
cellular component
0.68
pathway
0.65
interacting protein
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.55   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.55   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999999848
p_ni:  1.48e-7
p_wrong:  4e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999995165
p_ni:  0.000004506
p_wrong:  3.29e-7
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.998879346
p_ni:  0.000625634
p_wrong:  0.00049502
Score:  0.188
Data Source:  BioPlex,STRINGDB
CEP250
Tbio
Novelty:  0.08014712
Score:  0.971
Data Source:  STRINGDB
ODF2
Tbio
Novelty:  0.03203587
Score:  0.971
Data Source:  STRINGDB
PCM1
Tbio
Novelty:  0.02901589
Score:  0.963
Data Source:  STRINGDB
PCNT
Tbio
Novelty:  0.00369505
Score:  0.957
Data Source:  STRINGDB
CEP164
Tbio
Novelty:  0.04775724
Score:  0.955
Data Source:  STRINGDB
CEP135
Tbio
Novelty:  0.03507768
Score:  0.952
Data Source:  STRINGDB
CC2D2A
Tbio
Novelty:  0.03684487
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
2
3
79.3
hemoglobin measurement
1
1
1
30.9
total cholesterol measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
79.3
hemoglobin measurement
1
30.9
total cholesterol measurement
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centriolin
VGNC:13866
464704
Macaque
centriolin
700200
Mouse
MGI:1889576
26920
Rat
RGD:1305317
311886
Dog
centriolin
VGNC:51704
474817
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centriolin
Macaque
centriolin
Mouse
Rat
Dog
centriolin
Publication Statistics
PubMed Score 92.55
PubMed score by year
PubTator Score 31.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title