You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CNTNAP2
Contactin-associated protein-like 2

Protein Summary
Description
Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361727
  • ENSP00000354778
  • ENSG00000174469
  • ENST00000463592
  • ENSP00000486292
  • ENST00000613345
  • ENSP00000481057
  • ENSG00000278728
  • ENST00000649351
  • ENSP00000496805

Symbol
  • CASPR2
  • KIAA0868
  • CDFE
  • NRXN4
  • AUTS15
  • CASPR2
  • PTHSL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.97
transcription factor perturbation
0.94
PubMedID
0.86
cellular component
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.59   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.59   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0