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Tbio
CNTNAP1
Contactin-associated protein 1

Protein Summary
Description
Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264638
  • ENSP00000264638
  • ENSG00000108797

Symbol
  • CASPR
  • NRXN4
  • CHN3
  • P190
  • CASPR
  • NRXN4
  • CNTNAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
hub protein
0.94
gene perturbation
0.85
cell type or tissue
0.69
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.86   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.86   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.999995363
p_ni:  0.000004636
p_wrong:  1e-9
Data Source:  BioPlex
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.999994718
p_ni:  0.000005282
Data Source:  BioPlex
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.999805579
p_ni:  0.000192633
p_wrong:  0.000001789
Data Source:  BioPlex
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.999672773
p_ni:  0.000322965
p_wrong:  0.000004261
Data Source:  BioPlex
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.999255033
p_ni:  0.00074405
p_wrong:  9.16e-7
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.998000934
p_ni:  0.001953541
p_wrong:  0.000045525
Score:  0.151
Data Source:  BioPlex,STRINGDB
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.997684075
p_ni:  0.001944584
p_wrong:  0.00037134
Data Source:  BioPlex
SIL1
Tbio
Novelty:  0.00848561
p_int:  0.996496329
p_ni:  0.003499349
p_wrong:  0.000004322
Data Source:  BioPlex
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.964608551
p_ni:  0.035386709
p_wrong:  0.000004739
Data Source:  BioPlex
CD93
Tbio
Novelty:  0.01324003
p_int:  0.875025036
p_ni:  0.010350539
p_wrong:  0.114624424
Score:  0.324
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Neurofascin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Neurofascin interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
5
5
80.9
BMI-adjusted waist-hip ratio
2
5
5
78.5
waist circumference
1
2
2
43.8
triglyceride measurement
1
1
1
38.8
2
1
1
1.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
5
80.9
BMI-adjusted waist-hip ratio
5
78.5
waist circumference
2
43.8
triglyceride measurement
1
38.8
1
1.1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
contactin associated protein 1
VGNC:9240
454696
Macaque
contactin associated protein 1
574229
Mouse
MGI:1858201
53321
Rat
RGD:70902
84008
Dog
contactin associated protein 1
VGNC:39438
490960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
contactin associated protein 1
Macaque
contactin associated protein 1
Mouse
Rat
Dog
contactin associated protein 1
Publication Statistics
PubMed Score 167.86
PubMed score by year
PubTator Score 181.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title