Protein Summary
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. [provided by RefSeq, Sep 2016]
- ENST00000331830
- ENSP00000330633
- ENSG00000184144
- ENST00000638378
- ENSP00000492617
- ENST00000639302
- ENSP00000491671
- ENST00000640326
- ENSP00000492495
- AXT
- TAG1
- TAX1
- AXT
- TAX
- TAX1
- FAME5
- TAG-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.87 | ||
protein domain | 0.85 | ||
hub protein | 0.79 | ||
cell type or tissue | 0.76 | ||
cellular component | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 495.6 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 250 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 495.6 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 250 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (221)
Nearest Tclin Targets
Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | L1CAM interactions | ||||
Reactome | NCAM signaling for neurite out-growth | ||||
Reactome | NCAM1 interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
L1CAM interactions | ||||
NCAM signaling for neurite out-growth | ||||
NCAM1 interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (4)
Components (10)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 4 | 4 | 98.5 | |||||
basophil count | 2 | 2 | 2 | 92.1 | |||||
basophil percentage of leukocytes | 2 | 2 | 2 | 90.8 | |||||
red blood cell density measurement | 1 | 1 | 1 | 82.1 | |||||
risk-taking behaviour | 2 | 3 | 3 | 79.1 | |||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 98.5 | |||||
basophil count | 2 | 92.1 | |||||
basophil percentage of leukocytes | 2 | 90.8 | |||||
red blood cell density measurement | 1 | 82.1 | |||||
risk-taking behaviour | 3 | 79.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | contactin 2 | VGNC:6115 | 457662 | |||||
Macaque | contactin 2 | 574333 | ||||||
Mouse | MGI:104518 | 21367 | ||||||
Rat | RGD:3821 | 25356 | ||||||
Dog | contactin 2 | VGNC:39433 | 100685268 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | contactin 2 | |||||
Macaque | contactin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | contactin 2 | |||||
Publication Statistics
PubMed Score 495.60
PubMed score by year
PubTator Score 1289.74
PubTator score by year
Related Publications
Text Mined References (39)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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