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Tbio
CNTLN
Centlein

Protein Summary
Description
Required for centrosome cohesion and recruitment of CEP68 to centrosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380641
  • ENSP00000370015
  • ENSG00000044459
  • ENST00000380647
  • ENSP00000370021

Symbol
  • C9orf101
  • C9orf39
  • C9orf39
  • C9orf101
  • bA340N12.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
histone modification site profile
0.84
kinase perturbation
0.81
cellular component
0.79
molecular function
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.1   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.1   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
LAS2
Tbio
Novelty:  0.1135067
p_int:  1
Score:  0.371
Data Source:  BioPlex,STRINGDB
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.999995434
p_ni:  5.6e-8
p_wrong:  0.00000451
Score:  0.189
Data Source:  BioPlex,STRINGDB
ATG101
Tbio
Novelty:  0.03407206
p_int:  0.999994303
p_ni:  0.000005534
p_wrong:  1.63e-7
Data Source:  BioPlex
TPM1
Tbio
Novelty:  0.00261206
p_int:  0.984421545
p_ni:  4.44e-7
p_wrong:  0.015578012
Score:  0.213
Data Source:  BioPlex,STRINGDB
SPATC1
Tdark
Novelty:  0.26477487
Score:  0.925
Data Source:  STRINGDB
LRRC45
Tdark
Novelty:  0.38407505
Score:  0.804
Data Source:  STRINGDB
PCNT
Tbio
Novelty:  0.00369505
Score:  0.792
Data Source:  STRINGDB
CEP170
Tbio
Novelty:  0.05342931
Score:  0.754
Data Source:  STRINGDB
CROCC
Tbio
Novelty:  0.03718561
Score:  0.75
Data Source:  STRINGDB
NUP85
Tbio
Novelty:  0.02350514
Score:  0.749
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
2
3
63
2
1
1
1.1
56.8
BMI-adjusted waist circumference
1
2
2
53.1
alcohol use disorder measurement
1
1
0
5.9
31.4
waist-hip ratio
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
63
1
1.1
56.8
BMI-adjusted waist circumference
2
53.1
alcohol use disorder measurement
0
5.9
31.4
waist-hip ratio
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centlein
VGNC:4704
465007
Mouse
MGI:2443104
338349
Dog
centlein
VGNC:39431
481548
Horse
centlein
VGNC:16694
100052128
Cow
centlein [Source:HGNC Symbol;Acc:HGNC:23432]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centlein
Mouse
Dog
centlein
Horse
centlein
Cow
centlein [Source:HGNC Symbol;Acc:HGNC:23432]
Publication Statistics
PubMed Score 132.10
PubMed score by year
PubTator Score 15.72
PubTator score by year
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Related Publications
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PMID
Year
Title