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Tdark
CNST
Consortin

Protein Summary
Description
Required for targeting of connexins to the plasma membrane. Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366512
  • ENSP00000355469
  • ENSG00000162852
  • ENST00000366513
  • ENSP00000355470

Symbol
  • C1orf71
  • C1orf71
  • PPP1R64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
transcription factor binding site profile
0.89
tissue sample
0.76
histone modification site profile
0.73
microRNA
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.06   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.06   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999946
p_ni:  4e-9
p_wrong:  5e-8
Score:  0.668
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.99998679
p_ni:  1.4e-8
p_wrong:  0.000013197
Score:  0.644
Data Source:  BioPlex,STRINGDB
GJC1
Tbio
Novelty:  0.00375192
Score:  0.823
Data Source:  STRINGDB
GJB6
Tbio
Novelty:  0.00119317
Score:  0.785
Data Source:  STRINGDB
GGA2
Tbio
Novelty:  0.01750948
Score:  0.783
Data Source:  STRINGDB
GJB1
Tbio
Novelty:  0.00109019
Score:  0.771
Data Source:  STRINGDB
GJB2
Tbio
Novelty:  0.00056398
Score:  0.741
Data Source:  STRINGDB
GGA1
Tbio
Novelty:  0.00866392
Score:  0.716
Data Source:  STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.712
Data Source:  STRINGDB
LRP3
Tbio
Novelty:  0.09085132
Score:  0.682
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
28.1
hemolysis
1
1
0
21.2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
28.1
hemolysis
0
21.2
15.8
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
consortin, connexin sorting protein
VGNC:8245
456499
Macaque
consortin, connexin sorting protein
711764
Mouse
MGI:2445141
226744
Rat
RGD:1564833
498297
Dog
consortin, connexin sorting protein
VGNC:39428
611848
Species
Name
OMA
EggNOG
Inparanoid
Chimp
consortin, connexin sorting protein
Macaque
consortin, connexin sorting protein
Mouse
Rat
Dog
consortin, connexin sorting protein
Publication Statistics
PubMed Score 11.06
PubMed score by year
PubTator Score 5.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title