Protein Summary
Required for targeting of connexins to the plasma membrane. Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]
- ENST00000366512
- ENSP00000355469
- ENSG00000162852
- ENST00000366513
- ENSP00000355470
- C1orf71
- C1orf71
- PPP1R64
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.94 | ||
transcription factor binding site profile | 0.89 | ||
tissue sample | 0.76 | ||
histone modification site profile | 0.73 | ||
microRNA | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.06 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 16 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.06 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 16 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (16)
PPP1CC
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999999946
p_ni: 4e-9
p_wrong: 5e-8
Score: 0.668
Data Source: BioPlex,STRINGDB
PPP1CA
Family: Enzyme
Novelty: 0.00354658
p_int: 0.99998679
p_ni: 1.4e-8
p_wrong: 0.000013197
Score: 0.644
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (7)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein B measurement | 1 | 1 | 1 | 28.1 | |||||
hemolysis | 1 | 1 | 0 | 21.2 | 15.8 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein B measurement | 1 | 28.1 | |||||
hemolysis | 0 | 21.2 | 15.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | consortin, connexin sorting protein | VGNC:8245 | 456499 | |||||
Macaque | consortin, connexin sorting protein | 711764 | ||||||
Mouse | MGI:2445141 | 226744 | ||||||
Rat | RGD:1564833 | 498297 | ||||||
Dog | consortin, connexin sorting protein | VGNC:39428 | 611848 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | consortin, connexin sorting protein | |||||
Macaque | consortin, connexin sorting protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | consortin, connexin sorting protein | |||||
Publication Statistics
PubMed Score 11.06
PubMed score by year
PubTator Score 5.83
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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