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Tbio
CNRIP1
CB1 cannabinoid receptor-interacting protein 1

Protein Summary
Description
Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect. This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263655
  • ENSP00000263655
  • ENSG00000119865
  • ENST00000409559
  • ENSP00000386883

Symbol
  • C2orf32
  • CRIP1
  • C2orf32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.62
tissue sample
0.59
histone modification site profile
0.55
kinase perturbation
0.54
cell type or tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
UTP4
Tbio
Novelty:  0.06989008
p_int:  0.99999267
p_ni:  0.00000733
Score:  0.219
Data Source:  BioPlex,STRINGDB
C20orf203
Tdark
p_int:  0.980878891
p_ni:  0.019121
p_wrong:  1.1e-7
Data Source:  BioPlex
KCTD2
Tdark
Novelty:  0.42992811
p_int:  0.972796376
p_ni:  0.004786781
p_wrong:  0.022416843
Score:  0.237
Data Source:  BioPlex,STRINGDB
RBM18
Tdark
Novelty:  5.77641942
p_int:  0.971197348
p_ni:  0.018185993
p_wrong:  0.010616659
Score:  0.309
Data Source:  BioPlex,STRINGDB
PGLYRP1
Tbio
Novelty:  0.00231527
p_int:  0.89799899
p_ni:  0.101998752
p_wrong:  0.000002258
Score:  0.54
Data Source:  BioPlex,STRINGDB
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.89799899
p_ni:  0.101998752
p_wrong:  0.000002258
Data Source:  BioPlex
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.791
Data Source:  STRINGDB
PNO1
Tbio
Novelty:  0.05311566
Score:  0.718
Data Source:  STRINGDB
ETAA1
Tbio
Novelty:  0.07555913
Score:  0.714
Data Source:  STRINGDB
APLF
Tbio
Novelty:  0.01347476
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
81.1
platelet crit
2
1
2
78.4
3
3
0
1.1
77.7
mean platelet volume
2
1
2
77.4
myeloid white cell count
1
1
1
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
81.1
platelet crit
2
78.4
0
1.1
77.7
mean platelet volume
2
77.4
myeloid white cell count
1
64
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cannabinoid receptor interacting protein 1
VGNC:203
459291
Mouse
MGI:1917505
380686
Rat
RGD:1308373
364208
Dog
cannabinoid receptor interacting protein 1
VGNC:54520
612567
Horse
cannabinoid receptor interacting protein 1
VGNC:16689
100061844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cannabinoid receptor interacting protein 1
Mouse
Rat
Dog
cannabinoid receptor interacting protein 1
Horse
cannabinoid receptor interacting protein 1
Publication Statistics
PubMed Score 23.61
PubMed score by year
PubTator Score 2.05
PubTator score by year
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Related Publications
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PMID
Year
Title