Protein Summary
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of ...more
- ENST00000369499
- ENSP00000358511
- ENSG00000118432
- ENST00000369501
- ENSP00000358513
- ENST00000428600
- ENSP00000412192
- ENST00000468898
- ENSP00000420188
- ENST00000549890
- ENSP00000446819
- CNR
- CB1
- CNR
- CB-R
- CB1A
- CB1R
- CANN6
- CB1K5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.99 | ||
phenotype | 0.99 | ||
chemical | 0.88 | ||
microRNA | 0.84 | ||
disease | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1903.92 (req: < 5)
Gene RIFs: 380 (req: <= 3)
Antibodies: 546 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1903.92 (req: >= 5)
Gene RIFs: 380 (req: > 3)
Antibodies: 546 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 38
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2329
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (2329)
Protein-Protein Interactions (378)
Nearest Tclin Targets
Pathways (20)
Reactome (6)
KEGG (4)
PathwayCommons (2)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (47)
Functions (3)
Components (9)
Processes (35)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
gut microbiome measurement | 1 | 1 | 0 | 5.5 | 0.2 | ||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
gut microbiome measurement | 0 | 5.5 | 0.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cannabinoid receptor 1 | VGNC:12629 | 472066 | |||||
Macaque | cannabinoid receptor 1 | 574142 | ||||||
Mouse | MGI:104615 | 12801 | ||||||
Rat | RGD:2369 | 25248 | ||||||
Dog | cannabinoid receptor 1 | VGNC:39426 | 481913 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cannabinoid receptor 1 | |||||
Macaque | cannabinoid receptor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cannabinoid receptor 1 | |||||
Publication Statistics
PubMed Score 1903.92
PubMed score by year
PubTator Score 2145.35
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (433)
GeneRif Annotations (380)
Items per page:
0 of 0
PMID | Year | Title |
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