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Tdark
CNPY4
Protein canopy homolog 4

Protein Summary
Description
Plays a role in the regulation of the cell surface expression of TLR4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262932
  • ENSP00000262932
  • ENSG00000166997

Symbol
  • PRAT4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.88
tissue sample
0.59
cell type or tissue
0.51
transcription factor binding site profile
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
CHAD
Tbio
Novelty:  0.00879818
p_int:  0.999999949
p_ni:  5.1e-8
Score:  0.384
Data Source:  BioPlex,STRINGDB
PODN
Tbio
Novelty:  0.01466791
p_int:  0.999999938
p_ni:  6.2e-8
Score:  0.206
Data Source:  BioPlex,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.999999778
p_ni:  2.22e-7
Data Source:  BioPlex
KERA
Tbio
Novelty:  0.00789599
p_int:  0.999997001
p_ni:  8.42e-7
p_wrong:  0.000002157
Score:  0.195
Data Source:  BioPlex,STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.999607431
p_ni:  0.000189699
p_wrong:  0.00020287
Data Source:  BioPlex
LRIG1
Tbio
Novelty:  0.01078663
p_int:  0.99503589
p_ni:  0.000706096
p_wrong:  0.004258014
Score:  0.363
Data Source:  BioPlex,STRINGDB
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.994824097
p_ni:  0.001066071
p_wrong:  0.004109832
Score:  0.527
Data Source:  BioPlex,STRINGDB
LRRTM2
Tbio
Novelty:  0.08084156
p_int:  0.993564601
p_ni:  0.000172556
p_wrong:  0.006262843
Score:  0.221
Data Source:  BioPlex,STRINGDB
LRRC40
Tdark
Novelty:  2.43377466
Score:  0.745
Data Source:  STRINGDB
TLR4
Tchem
Novelty:  0.00010863
Score:  0.707
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
78.3
FEV/FEC ratio
1
1
1
62.5
body height
1
1
1
62.1
1
1
0
1.3
61
1
1
0
1.1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
78.3
FEV/FEC ratio
1
62.5
body height
1
62.1
0
1.3
61
0
1.1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
canopy FGF signaling regulator 4
VGNC:4311
463589
Macaque
canopy FGF signaling regulator 4
719080
Mouse
MGI:1913705
66455
Rat
RGD:1307636
363886
Dog
canopy FGF signaling regulator 4
VGNC:39425
489845
Species
Name
OMA
EggNOG
Inparanoid
Chimp
canopy FGF signaling regulator 4
Macaque
canopy FGF signaling regulator 4
Mouse
Rat
Dog
canopy FGF signaling regulator 4
Publication Statistics
PubMed Score 1.14
PubMed score by year
PubTator Score 0.88
PubTator score by year
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Related Publications
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PMID
Year
Title