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Tbio
CNPY3
Protein canopy homolog 3

Protein Summary
Description
Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity). This gene encodes a protein that binds members of the toll-like receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrough transcription occurs between this locus and the downstream GNMT (glycine N-methyltransferase) gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372836
  • ENSP00000361926
  • ENSG00000137161

Symbol
  • CTG4A
  • ERDA5
  • PRAT4A
  • TNRC5
  • CAG4A
  • ERDA5
  • TNRC5
  • EIEE60
  • PRAT4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
transcription factor binding site profile
0.76
interacting protein
0.71
virus perturbation
0.68
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
LRRC40
Tdark
Novelty:  2.43377466
p_int:  0.999998123
p_ni:  0.000001877
Score:  0.952
Data Source:  BioPlex,STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.999925135
p_ni:  0.000074865
Data Source:  BioPlex
VASN
Tbio
Novelty:  0.05424159
p_int:  0.999867522
p_ni:  0.000132478
Data Source:  BioPlex
PXDN
Tbio
Novelty:  0.00935722
p_int:  0.999203091
p_ni:  0.000796909
Data Source:  BioPlex
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.998909954
p_ni:  0.001090046
Score:  0.448
Data Source:  BioPlex,STRINGDB
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.998797489
p_ni:  0.001202511
Data Source:  BioPlex
NRROS
Tbio
Novelty:  0.08976002
p_int:  0.998750809
p_ni:  0.001249191
Score:  0.165
Data Source:  BioPlex,STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.998092439
p_ni:  0.001907561
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.997368125
p_ni:  0.002631875
Data Source:  BioPlex
LRRTM2
Tbio
Novelty:  0.08084156
p_int:  0.995410001
p_ni:  0.004589999
Score:  0.184
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Toll-like Receptor Cascades
Reactome
Trafficking and processing of endosomal TLR
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Toll-like Receptor Cascades
Trafficking and processing of endosomal TLR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
3
4
4
89.1
apolipoprotein A 1 measurement
4
4
5
86.9
high density lipoprotein cholesterol measurement
10
5
11
86.5
blood protein measurement
1
2
2
80.3
homocysteine measurement
1
1
1
71
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
4
89.1
apolipoprotein A 1 measurement
5
86.9
high density lipoprotein cholesterol measurement
11
86.5
blood protein measurement
2
80.3
homocysteine measurement
1
71
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
canopy FGF signaling regulator 3
VGNC:2677
462702
Mouse
MGI:1919279
72029
Rat
RGD:1597709
685174
Dog
canopy FGF signaling regulator 3
VGNC:39424
609385
Horse
canopy FGF signaling regulator 3
VGNC:16685
100067096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
canopy FGF signaling regulator 3
Mouse
Rat
Dog
canopy FGF signaling regulator 3
Horse
canopy FGF signaling regulator 3
Publication Statistics
PubMed Score 7.92
PubMed score by year
PubTator Score 6.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title