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Tbio
CNP
2',3'-cyclic-nucleotide 3'-phosphodiesterase

Protein Summary
Description
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393888
  • ENSP00000377466
  • ENSG00000173786
  • ENST00000393892
  • ENSP00000377470

Symbol
  • CNP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
disease perturbation
0.9
virus perturbation
0.9
co-expressed gene
0.89
interacting protein
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.88   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 484   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.88   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SIRT3
Tchem
Family:  Epigenetic
Novelty:  0.00101187
p_int:  0.957016598
p_ni:  0.042983402
Score:  0.532
Data Source:  BioPlex,STRINGDB
MBP
Tbio
Novelty:  0.00016333
Score:  0.841
Data Source:  STRINGDB
MAG
Tchem
Novelty:  0.00085621
Score:  0.772
Data Source:  STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
Score:  0.757
Data Source:  STRINGDB
PLP1
Tbio
Novelty:  0.00129083
Score:  0.755
Data Source:  STRINGDB
ADAP1
Tbio
Novelty:  0.03287486
Score:  0.723
Data Source:  STRINGDB
GFAP
Tbio
Novelty:  0.00020932
Score:  0.716
Data Source:  STRINGDB
OLIG2
Tbio
Family:  TF
Novelty:  0.0015221
Score:  0.681
Data Source:  STRINGDB
NPPC
Tbio
Novelty:  0.00114199
Score:  0.677
Data Source:  STRINGDB
PLLP
Tbio
Family:  IC
Novelty:  0.02222236
Score:  0.651
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Glial Cell Differentiation
WikiPathways
MECP2 and Associated Rett Syndrome
WikiPathways
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Name
Explore in Pharos
Explore in Source
Glial Cell Differentiation
MECP2 and Associated Rett Syndrome
Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
3
3
75.8
blood protein measurement
1
1
1
58.1
reticulocyte measurement
1
1
1
33.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
75.8
blood protein measurement
1
58.1
reticulocyte measurement
1
33.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
2',3'-cyclic nucleotide 3' phosphodiesterase
VGNC:9415
454673
Macaque
2',3'-cyclic nucleotide 3' phosphodiesterase
641337
Dog
2',3'-cyclic nucleotide 3' phosphodiesterase
VGNC:39421
607694
Horse
2',3'-cyclic nucleotide 3' phosphodiesterase
VGNC:16683
100066401
Pig
2',3'-cyclic nucleotide 3' phosphodiesterase
100511587
Species
Name
OMA
EggNOG
Inparanoid
Chimp
2',3'-cyclic nucleotide 3' phosphodiesterase
Macaque
2',3'-cyclic nucleotide 3' phosphodiesterase
Dog
2',3'-cyclic nucleotide 3' phosphodiesterase
Horse
2',3'-cyclic nucleotide 3' phosphodiesterase
Pig
2',3'-cyclic nucleotide 3' phosphodiesterase
Publication Statistics
PubMed Score 147.88
PubMed score by year
PubTator Score 498.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title