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Tbio
CNOT8
CCR4-NOT transcription complex subunit 8

Protein Summary
Description
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285896
  • ENSP00000285896
  • ENSG00000155508
  • ENST00000403027
  • ENSP00000384747
  • ENST00000517876
  • ENSP00000430493
  • ENST00000519404
  • ENSP00000430833
  • ENST00000520671
  • ENSP00000428305
  • ENST00000521450
  • ENSP00000431034
  • ENST00000521583
  • ENSP00000429882
  • ENST00000523698
  • ENSP00000428565

Symbol
  • CALIF
  • POP2
  • CAF1
  • POP2
  • CALIF
  • Caf1b
  • hCAF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor binding site profile
0.93
kinase perturbation
0.91
transcription factor perturbation
0.91
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.9   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.9   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999996951
p_ni:  0.000003049
Score:  0.999
Data Source:  BioPlex,STRINGDB
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.99998457
p_ni:  0.00001543
Score:  0.712
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999975331
p_ni:  0.000024668
Score:  0.994
Data Source:  BioPlex,STRINGDB
TEX13A
Tdark
Novelty:  1.13928013
p_int:  0.999930829
p_ni:  0.000069085
p_wrong:  8.6e-8
Score:  0.392
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.999902366
p_ni:  0.000097606
p_wrong:  2.8e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999816195
p_ni:  0.000183804
p_wrong:  1e-9
Score:  0.532
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999765871
p_ni:  0.000234129
Data Source:  BioPlex
GADD45B
Tbio
Novelty:  0.00611526
p_int:  0.999030141
p_ni:  0.000969859
Score:  0.54
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.998030718
p_ni:  0.001969281
p_wrong:  1e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
MMP7
Tchem
Family:  Enzyme
Novelty:  0.00080093
p_int:  0.99508596
p_ni:  0.00491404
Score:  0.542
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
62.1
reticulocyte count
2
2
2
50.4
mean corpuscular hemoglobin
1
1
1
13.3
mean corpuscular volume
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
62.1
reticulocyte count
2
50.4
mean corpuscular hemoglobin
1
13.3
mean corpuscular volume
1
8.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 8
VGNC:6842
462213
Macaque
CCR4-NOT transcription complex subunit 8
714813
Mouse
MGI:1916375
69125
Rat
RGD:1306401
363603
Dog
CCR4-NOT transcription complex subunit 8
VGNC:39419
489162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 8
Macaque
CCR4-NOT transcription complex subunit 8
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 8
Publication Statistics
PubMed Score 57.90
PubMed score by year
PubTator Score 2365.44
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title