Tchem CNOT7 CCR4-NOT transcription complex subunit 7

Protein Summary

Description

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q9UIV1
• A8MZM5
• B3KMP1
• B3KN35
• D3DSP6
• G3V108
• Q7Z530

Gene Name

• CNOT7

Ensembl ID

• ENST00000361272
• ENSP00000355279
• ENSG00000198791
• ENST00000523917
• ENSP00000429093

Symbol

• CAF1
• CAF1
• CAF-1
• Caf1a
• hCAF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
kinase perturbation	0.91
biological process	0.89
protein complex	0.87
molecular function	0.86

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ccr4-not Transcription Complex Subunit 7

DTO Classes

Protein / Transcription Factor / Ccr4-not Transcription Complex Subunit 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0