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Tchem
CNOT7
CCR4-NOT transcription complex subunit 7

Protein Summary
Description
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361272
  • ENSP00000355279
  • ENSG00000198791
  • ENST00000523917
  • ENSP00000429093

Symbol
  • CAF1
  • CAF1
  • CAF-1
  • Caf1a
  • hCAF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.91
biological process
0.89
protein complex
0.87
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.83   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.83   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (109)
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999999996
p_ni:  4e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
CNOT6L
Tbio
Novelty:  0.06038336
p_int:  0.99999921
p_ni:  7.9e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TOB2
Tbio
Novelty:  0.02809091
p_int:  0.999998928
p_ni:  2.79e-7
p_wrong:  7.93e-7
Score:  0.956
Data Source:  BioPlex,STRINGDB
CNOT6
Tbio
Novelty:  0.03605299
p_int:  0.999996805
p_ni:  0.000003124
p_wrong:  7e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.999991842
p_ni:  0.000008153
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999977638
p_ni:  0.000022362
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CNOT2
Tbio
Novelty:  0.01886737
p_int:  0.999972298
p_ni:  0.000027702
Score:  0.999
Data Source:  BioPlex,STRINGDB
BTG3
Tbio
Novelty:  0.01541026
p_int:  0.999928096
p_ni:  0.000071882
p_wrong:  2.3e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999923588
p_ni:  0.000076411
Score:  0.898
Data Source:  BioPlex,STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
p_int:  0.999851971
p_ni:  0.000148029
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (41)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.1
53.7
self reported educational attainment
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
53.7
self reported educational attainment
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 7 pseudogene
461297
Macaque
CCR4-NOT transcription complex subunit 7
702192
Mouse
MGI:1298230
18983
Rat
RGD:1305313
306492
Dog
CCR4-NOT transcription complex subunit 7
VGNC:39418
482895
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 7 pseudogene
Macaque
CCR4-NOT transcription complex subunit 7
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 7
Publication Statistics
PubMed Score 26.83
PubMed score by year
PubTator Score 18.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title