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Tbio
CNOT6L
CCR4-NOT transcription complex subunit 6-like

Protein Summary
Description
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000504123
  • ENSP00000424896
  • ENSG00000138767

Symbol
  • CCR4B
  • CCR4b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.8
transcription factor binding site profile
0.75
biological process
0.73
microRNA
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.52   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.52   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999999898
p_ni:  1.02e-7
Score:  0.84
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999999759
p_ni:  2.4e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.999999536
p_ni:  4.63e-7
p_wrong:  1e-9
Score:  0.987
Data Source:  BioPlex,STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.99999921
p_ni:  7.9e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.999998232
p_ni:  0.000001768
Score:  0.992
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999998171
p_ni:  0.000001829
Data Source:  BioPlex
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999997008
p_ni:  0.000002991
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
TEX13A
Tdark
Novelty:  1.13928013
p_int:  0.999990109
p_ni:  0.000009891
Score:  0.571
Data Source:  BioPlex,STRINGDB
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999971466
p_ni:  0.000028525
p_wrong:  9e-9
Score:  0.799
Data Source:  BioPlex,STRINGDB
GADD45B
Tbio
Novelty:  0.00611526
p_int:  0.999331931
p_ni:  0.000668069
Score:  0.549
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Competing endogenous RNAs (ceRNAs) regulate PTEN translation (R-HSA-8948700)

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Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
45.5
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443154
231464
Dog
CCR4-NOT transcription complex subunit 6 like
VGNC:39417
487817
Horse
CCR4-NOT transcription complex subunit 6 like
VGNC:16679
100059049
Pig
CCR4-NOT transcription complex subunit 6 like
100512848
Opossum
CCR4-NOT transcription complex subunit 6 like
100009944
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
CCR4-NOT transcription complex subunit 6 like
Horse
CCR4-NOT transcription complex subunit 6 like
Pig
CCR4-NOT transcription complex subunit 6 like
Opossum
CCR4-NOT transcription complex subunit 6 like
Publication Statistics
PubMed Score 25.52
PubMed score by year
PubTator Score 5.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title