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Tbio
CNOT6
CCR4-NOT transcription complex subunit 6

Protein Summary
Description
Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261951
  • ENSP00000261951
  • ENSG00000113300
  • ENST00000393356
  • ENSP00000377024
  • ENST00000618123
  • ENSP00000481893

Symbol
  • CCR4
  • CCR4a
  • KIAA1194
  • CCR4
  • Ccr4a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor perturbation
0.97
kinase perturbation
0.93
microRNA
0.9
gene perturbation
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.67   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.67   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.784
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.999999939
p_ni:  6.1e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.99999991
p_ni:  8.9e-8
p_wrong:  1e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999999817
p_ni:  1.83e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.99999928
p_ni:  7.2e-7
Data Source:  BioPlex
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.999997426
p_ni:  0.000002574
Score:  0.992
Data Source:  BioPlex,STRINGDB
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999996827
p_ni:  0.000003165
p_wrong:  9e-9
Score:  0.734
Data Source:  BioPlex,STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.999996805
p_ni:  0.000003124
p_wrong:  7e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
TEX13A
Tdark
Novelty:  1.13928013
p_int:  0.99999484
p_ni:  0.000005154
p_wrong:  6e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
MMP7
Tchem
Family:  Enzyme
Novelty:  0.00080093
p_int:  0.999445161
p_ni:  0.000554834
p_wrong:  4e-9
Score:  0.729
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Developmental Biology
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
71.1
mean corpuscular volume
1
1
1
53.1
serum albumin measurement
2
2
2
46.9
mean reticulocyte volume
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
71.1
mean corpuscular volume
1
53.1
serum albumin measurement
2
46.9
mean reticulocyte volume
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 6
VGNC:6841
462338
Macaque
CCR4-NOT transcription complex subunit 6
716286
Mouse
MGI:2144529
104625
Rat
RGD:1310783
287249
Dog
CCR4-NOT transcription complex subunit 6
VGNC:39416
481463
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 6
Macaque
CCR4-NOT transcription complex subunit 6
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 6
Publication Statistics
PubMed Score 33.67
PubMed score by year
PubTator Score 6.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title