Tbio CNOT3 CCR4-NOT transcription complex subunit 3

Protein Summary

Description

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.

Uniprot Accession IDs

• O75175
• Q9NZN7
• Q9UF76

Gene Name

• CNOT3

Ensembl ID

• ENST00000221232
• ENSP00000221232
• ENSG00000088038
• ENST00000358389
• ENSP00000351159
• ENST00000610883
• ENSP00000480258
• ENSG00000274941
• ENST00000611252
• ENSP00000483968
• ENSG00000275979
• ENST00000612924
• ENSP00000480585
• ENSG00000274176
• ENST00000613528
• ENSP00000483604
• ENSG00000277615
• ENST00000613752
• ENSP00000481681
• ENSG00000273943
• ENST00000614649
• ENSP00000484794
• ENST00000615030
• ENSP00000480697
• ENSG00000274616
• ENST00000616359
• ENSP00000484040
• ENST00000616910
• ENSP00000480876
• ENST00000617982
• ENSP00000479987
• ENSG00000277600
• ENST00000618405
• ENSP00000481924
• ENSG00000277114
• ENST00000619567
• ENSP00000483882
• ENST00000619854
• ENSP00000483431
• ENST00000620060
• ENSP00000483036
• ENST00000620419
• ENSP00000478956
• ENSG00000276082
• ENST00000620573
• ENSP00000480988
• ENST00000620970
• ENSP00000483692
• ENST00000622131
• ENSP00000478280

Symbol

• KIAA0691
• LENG2
• NOT3
• NOT3
• LENG2
• NOT3H

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.8
hub protein	0.75
transcription factor binding site profile	0.75
histone modification site profile	0.69
biological process	0.67

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ccr4-not Transcription Complex Subunit 3

DTO Classes

Protein / Transcription Factor / Ccr4-not Transcription Complex Subunit 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.52   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.52   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (120)

Explore Interacting Targets

1 – 10 of 120

• See Interactions on String-DB

CNOT6

Tbio

Novelty:  0.03605299

p_int:  0.999999817

p_ni:  1.83e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

TNKS1BP1

Tbio

Family:  Enzyme

Novelty:  0.21682007

p_int:  0.999997871

p_ni:  0.000002129

Score:  0.934

Data Source:  BioPlex,STRINGDB

CNOT6L

Tbio

Novelty:  0.06038336

p_int:  0.999997008

p_ni:  0.000002991

p_wrong:  1e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

CNOT8

Tbio

Novelty:  0.01700084

p_int:  0.999996951

p_ni:  0.000003049

Score:  0.999

Data Source:  BioPlex,STRINGDB

CNOT2

Tbio

Novelty:  0.01886737

p_int:  0.999995839

p_ni:  0.000004161

Score:  0.999

Data Source:  BioPlex,STRINGDB

NANOS2

Tbio

Novelty:  0.01489157

p_int:  0.999995548

p_ni:  0.000004452

Score:  0.756

Data Source:  BioPlex,STRINGDB

BTG3

Tbio

Novelty:  0.01541026

p_int:  0.999994853

p_ni:  0.000005147

p_wrong:  1e-9

Score:  0.222

Data Source:  BioPlex,STRINGDB

CNOT11

Tbio

Novelty:  0.01687183

p_int:  0.999993631

p_ni:  0.00000637

Score:  0.995

Data Source:  BioPlex,STRINGDB

TOB1

Tbio

Novelty:  0.0163328

p_int:  0.999991484

p_ni:  0.000008516

Score:  0.978

Data Source:  BioPlex,STRINGDB

CNOT1

Tbio

Novelty:  0.00362753

p_int:  0.999990534

p_ni:  0.000009467

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (9)

KEGG (1)

Deadenylation of mRNA (R-HSA-429947)

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5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Deadenylation of mRNA	22 targets	R-HSA-429947
Reactome	Deadenylation-dependent mRNA decay	53 targets	R-HSA-429914
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854

Name	Explore in Pharos	Explore in Source
Deadenylation of mRNA	22 targets	R-HSA-429947
Deadenylation-dependent mRNA decay	53 targets	R-HSA-429914
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism of RNA	686 targets	R-HSA-8953854

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Components (5)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
CCR4-NOT complex	Inferred from Direct Assay (IDA)	UniProtKB
CCR4-NOT core complex	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
P-body	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
cytosol	Traceable Author Statement (TAS)	Reactome
nucleus	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations (null)

No disease associations found

GWAS Traits (304)

Items per page:

5

1 – 5 of 304

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	ENSG00000088038	2	3	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	ENSG00000277600	2	3	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	ENSG00000277114	2	3	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	ENSG00000274616	2	3	3	18.1	97.7
creatine kinase measurement	EFO_0004534	ENSG00000274616	5	4	8		96.6

Items per page:

5

1 – 5 of 304

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	3	18.1	97.7
alkaline phosphatase measurement	EFO_0004533	3	18.1	97.7
creatine kinase measurement	EFO_0004534	8		96.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Cytoplasm
Developmental protein
Nucleus
Phosphoprotein
Reference proteome
Repressor
RNA-mediated gene silencing
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
adiponectin measurement
alcoholic liver cirrhosis
alkaline phosphatase measurement
amino acid measurement
antioxidant measurement
arm span
asparaginase hypersensitivity
aspartate aminotransferase measurement
birth weight
blood metabolite measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CCR4-NOT transcription complex subunit 3	VGNC:10973	107969798
Macaque	CCR4-NOT transcription complex subunit 3		693292
Mouse	CCR4-NOT transcription complex, subunit 3	MGI:2385261	232791
Rat	CCR4-NOT transcription complex, subunit 3	RGD:1304771	308311
Dog	CCR4-NOT transcription complex subunit 3	VGNC:39414	484312

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CCR4-NOT transcription complex subunit 3
Macaque	CCR4-NOT transcription complex subunit 3
Mouse	CCR4-NOT transcription complex, subunit 3
Rat	CCR4-NOT transcription complex, subunit 3
Dog	CCR4-NOT transcription complex subunit 3

Publication Statistics

PubMed Score 45.52

PubMed score by year

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PubTator Score 14.93

PubTator score by year

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Related Publications

Text Mined References (32)

GeneRif Annotations (11)

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10

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PMID	Year	Title