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Tbio
CNOT3
CCR4-NOT transcription complex subunit 3

Protein Summary
Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221232
  • ENSP00000221232
  • ENSG00000088038
  • ENST00000358389
  • ENSP00000351159
  • ENST00000610883
  • ENSP00000480258
  • ENSG00000274941
  • ENST00000611252
  • ENSP00000483968
  • ENSG00000275979
  • ENST00000612924
  • ENSP00000480585
  • ENSG00000274176
  • ENST00000613528
  • ENSP00000483604
  • ENSG00000277615
  • ENST00000613752
  • ENSP00000481681
  • ENSG00000273943
  • ENST00000614649
  • ENSP00000484794
  • ENST00000615030
  • ENSP00000480697
  • ENSG00000274616
  • ENST00000616359
  • ENSP00000484040
  • ENST00000616910
  • ENSP00000480876
  • ENST00000617982
  • ENSP00000479987
  • ENSG00000277600
  • ENST00000618405
  • ENSP00000481924
  • ENSG00000277114
  • ENST00000619567
  • ENSP00000483882
  • ENST00000619854
  • ENSP00000483431
  • ENST00000620060
  • ENSP00000483036
  • ENST00000620419
  • ENSP00000478956
  • ENSG00000276082
  • ENST00000620573
  • ENSP00000480988
  • ENST00000620970
  • ENSP00000483692
  • ENST00000622131
  • ENSP00000478280

Symbol
  • KIAA0691
  • LENG2
  • NOT3
  • NOT3
  • LENG2
  • NOT3H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.8
hub protein
0.75
transcription factor binding site profile
0.75
histone modification site profile
0.69
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0