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Tbio
CNOT3
CCR4-NOT transcription complex subunit 3

Protein Summary
Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221232
  • ENSP00000221232
  • ENSG00000088038
  • ENST00000358389
  • ENSP00000351159
  • ENST00000610883
  • ENSP00000480258
  • ENSG00000274941
  • ENST00000611252
  • ENSP00000483968
  • ENSG00000275979
  • ENST00000612924
  • ENSP00000480585
  • ENSG00000274176
  • ENST00000613528
  • ENSP00000483604
  • ENSG00000277615
  • ENST00000613752
  • ENSP00000481681
  • ENSG00000273943
  • ENST00000614649
  • ENSP00000484794
  • ENST00000615030
  • ENSP00000480697
  • ENSG00000274616
  • ENST00000616359
  • ENSP00000484040
  • ENST00000616910
  • ENSP00000480876
  • ENST00000617982
  • ENSP00000479987
  • ENSG00000277600
  • ENST00000618405
  • ENSP00000481924
  • ENSG00000277114
  • ENST00000619567
  • ENSP00000483882
  • ENST00000619854
  • ENSP00000483431
  • ENST00000620060
  • ENSP00000483036
  • ENST00000620419
  • ENSP00000478956
  • ENSG00000276082
  • ENST00000620573
  • ENSP00000480988
  • ENST00000620970
  • ENSP00000483692
  • ENST00000622131
  • ENSP00000478280

Symbol
  • KIAA0691
  • LENG2
  • NOT3
  • NOT3
  • LENG2
  • NOT3H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.8
hub protein
0.75
transcription factor binding site profile
0.75
histone modification site profile
0.69
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.52   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.52   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
CNOT6
Tbio
Novelty:  0.03605299
p_int:  0.999999817
p_ni:  1.83e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
TNKS1BP1
Tbio
Family:  Enzyme
Novelty:  0.21682007
p_int:  0.999997871
p_ni:  0.000002129
Score:  0.934
Data Source:  BioPlex,STRINGDB
CNOT6L
Tbio
Novelty:  0.06038336
p_int:  0.999997008
p_ni:  0.000002991
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
CNOT8
Tbio
Novelty:  0.01700084
p_int:  0.999996951
p_ni:  0.000003049
Score:  0.999
Data Source:  BioPlex,STRINGDB
CNOT2
Tbio
Novelty:  0.01886737
p_int:  0.999995839
p_ni:  0.000004161
Score:  0.999
Data Source:  BioPlex,STRINGDB
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999995548
p_ni:  0.000004452
Score:  0.756
Data Source:  BioPlex,STRINGDB
BTG3
Tbio
Novelty:  0.01541026
p_int:  0.999994853
p_ni:  0.000005147
p_wrong:  1e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999993631
p_ni:  0.00000637
Score:  0.995
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.999991484
p_ni:  0.000008516
Score:  0.978
Data Source:  BioPlex,STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
p_int:  0.999990534
p_ni:  0.000009467
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (304)
Items per page:
1 – 5 of 304
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
alkaline phosphatase measurement
2
3
3
18.1
97.7
creatine kinase measurement
5
4
8
96.6
Items per page:
1 – 5 of 304
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
alkaline phosphatase measurement
3
18.1
97.7
creatine kinase measurement
8
96.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 3
VGNC:10973
107969798
Macaque
CCR4-NOT transcription complex subunit 3
693292
Mouse
MGI:2385261
232791
Rat
RGD:1304771
308311
Dog
CCR4-NOT transcription complex subunit 3
VGNC:39414
484312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 3
Macaque
CCR4-NOT transcription complex subunit 3
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 3
Publication Statistics
PubMed Score 45.52
PubMed score by year
PubTator Score 14.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title