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Tbio
CNOT2
CCR4-NOT transcription complex subunit 2

Protein Summary
Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity. This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of pol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229195
  • ENSP00000229195
  • ENSG00000111596
  • ENST00000418359
  • ENSP00000412091
  • ENST00000551043
  • ENSP00000449260
  • ENST00000551483
  • ENSP00000448883

Symbol
  • CDC36
  • NOT2
  • NOT2
  • CDC36
  • NOT2H
  • HSPC131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.97
biological process
0.86
molecular function
0.84
protein complex
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.04   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.04   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999999273
p_ni:  7.27e-7
Score:  0.81
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999999129
p_ni:  8.71e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.999997014
p_ni:  0.000002986
Score:  0.963
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999995839
p_ni:  0.000004161
Score:  0.999
Data Source:  BioPlex,STRINGDB
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999988259
p_ni:  0.000011741
Score:  0.55
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999987524
p_ni:  0.000012476
Data Source:  BioPlex
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.999980434
p_ni:  0.000019566
Score:  0.982
Data Source:  BioPlex,STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.999972298
p_ni:  0.000027702
Score:  0.999
Data Source:  BioPlex,STRINGDB
GADD45B
Tbio
Novelty:  0.00611526
p_int:  0.999639365
p_ni:  0.000360635
Score:  0.558
Data Source:  BioPlex,STRINGDB
MMP7
Tchem
Family:  Enzyme
Novelty:  0.00080093
p_int:  0.999250981
p_ni:  0.000749019
Score:  0.663
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
53.7
appendicular lean mass
1
1
1
33.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
53.7
appendicular lean mass
1
33.8
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 2
VGNC:12898
452072
Macaque
CCR4-NOT transcription complex subunit 2
718501
Mouse
MGI:1919318
72068
Rat
RGD:1311672
299805
Dog
CCR4-NOT transcription complex subunit 2
VGNC:39413
474446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 2
Macaque
CCR4-NOT transcription complex subunit 2
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 2
Publication Statistics
PubMed Score 66.04
PubMed score by year
PubTator Score 15.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title