You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CNOT11
CCR4-NOT transcription complex subunit 11

Protein Summary
Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289382
  • ENSP00000289382
  • ENSG00000158435

Symbol
  • C2orf29
  • C40
  • C2orf29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
interacting protein
0.86
cell type or tissue
0.85
protein complex
0.83
histone modification site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.999999996
p_ni:  4e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
CNOT6
Tbio
Novelty:  0.03605299
p_int:  0.99999991
p_ni:  8.9e-8
p_wrong:  1e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
CNOT6L
Tbio
Novelty:  0.06038336
p_int:  0.999999759
p_ni:  2.4e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
CNOT2
Tbio
Novelty:  0.01886737
p_int:  0.999999129
p_ni:  8.71e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999996879
p_ni:  0.000003121
Score:  0.873
Data Source:  BioPlex,STRINGDB
TNKS1BP1
Tbio
Family:  Enzyme
Novelty:  0.21682007
p_int:  0.999996445
p_ni:  0.000003555
Score:  0.99
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999993631
p_ni:  0.00000637
Score:  0.995
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.999988947
p_ni:  0.00001105
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999987442
p_ni:  0.000012558
Score:  0.826
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999981738
p_ni:  0.000018002
p_wrong:  2.61e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
60.5
reticulocyte count
1
1
1
51.7
reticulocyte measurement
2
1
2
46.9
myeloid white cell count
1
1
1
35
granulocyte count
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
60.5
reticulocyte count
1
51.7
reticulocyte measurement
2
46.9
myeloid white cell count
1
35
granulocyte count
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 11
VGNC:207
743599
Macaque
CCR4-NOT transcription complex subunit 11
710844
Mouse
MGI:106580
52846
Rat
RGD:1560909
363221
Dog
CCR4-NOT transcription complex subunit 11
VGNC:39412
481334
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 11
Macaque
CCR4-NOT transcription complex subunit 11
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 11
Publication Statistics
PubMed Score 51.83
PubMed score by year
PubTator Score 123.58
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title