Tbio CNOT11 CCR4-NOT transcription complex subunit 11

Protein Summary

Description

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

Uniprot Accession IDs

• Q9UKZ1
• Q6P2M9
• Q8N681

Gene Name

• CNOT11

Ensembl ID

• ENST00000289382
• ENSP00000289382
• ENSG00000158435

Symbol

• C2orf29
• C40
• C2orf29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
interacting protein	0.86
cell type or tissue	0.85
protein complex	0.83
histone modification site profile	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.05   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.05   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0