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Tbio
CNNM2
Metal transporter CNNM2

Protein Summary
Description
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369875
  • ENSP00000358891
  • ENSG00000148842
  • ENST00000369878
  • ENSP00000358894
  • ENST00000433628
  • ENSP00000392875

Symbol
  • ACDP2
  • ACDP2
  • HOMG6
  • HOMGSMR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
disease perturbation
0.9
trait
0.75
histone modification site profile
0.74
tissue sample
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.45   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.45   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
PTP4A1
Tchem
Family:  Enzyme
Novelty:  0.02863007
p_int:  0.999495999
p_ni:  0.000504001
Score:  0.982
Data Source:  BioPlex,STRINGDB
ARL15
Tbio
Family:  Enzyme
Novelty:  0.09327102
p_int:  0.987953544
p_ni:  0.012046456
Score:  0.335
Data Source:  BioPlex,STRINGDB
PTP4A2
Tchem
Family:  Enzyme
Novelty:  0.0083639
p_int:  0.98390447
p_ni:  0.01609553
Score:  0.839
Data Source:  BioPlex,STRINGDB
MIA3
Tbio
Novelty:  0.02784348
Score:  0.779
Data Source:  STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
Score:  0.747
Data Source:  STRINGDB
PTP4A3
Tchem
Family:  Enzyme
Novelty:  0.01185448
Score:  0.742
Data Source:  STRINGDB
PLPP3
Tbio
Family:  Enzyme
Novelty:  0.01655047
Score:  0.73
Data Source:  STRINGDB
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
Score:  0.712
Data Source:  STRINGDB
SLC41A1
Tbio
Family:  Transporter
Novelty:  0.01442757
Score:  0.708
Data Source:  STRINGDB
TRPM6
Tchem
Family:  Kinase
Novelty:  0.00594821
Score:  0.697
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (60)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
3
6
97.8
reticulocyte measurement
3
2
3
95.6
17
17
5
1.1
94.7
testosterone measurement
5
4
5
94.2
9
7
4
1.1
93
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
97.8
reticulocyte measurement
3
95.6
5
1.1
94.7
testosterone measurement
5
94.2
4
1.1
93
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin and CBS domain divalent metal cation transport mediator 2
VGNC:1609
450705
Macaque
cyclin and CBS domain divalent metal cation transport mediator 2
714238
Mouse
MGI:2151054
94219
Rat
RGD:1308162
294014
Dog
cyclin and CBS domain divalent metal cation transport mediator 2
VGNC:39407
486866
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin and CBS domain divalent metal cation transport mediator 2
Macaque
cyclin and CBS domain divalent metal cation transport mediator 2
Mouse
Rat
Dog
cyclin and CBS domain divalent metal cation transport mediator 2
Publication Statistics
PubMed Score 38.45
PubMed score by year
PubTator Score 18.69
PubTator score by year
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Related Publications
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PMID
Year
Title