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Tdark
CNNM1
Metal transporter CNNM1

Protein Summary
Description
Probable metal transporter. This gene encodes a member of the ancient conserved domain protein family. The encoded protein may bind copper. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356713
  • ENSP00000349147
  • ENSG00000119946

Symbol
  • ACDP1
  • ACDP1
  • CLP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
microRNA
0.81
phenotype
0.66
PubMedID
0.62
small molecule perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
PTP4A1
Tchem
Family:  Enzyme
Novelty:  0.02863007
p_int:  0.999999649
p_ni:  3.51e-7
Score:  0.791
Data Source:  BioPlex,STRINGDB
ARL15
Tbio
Family:  Enzyme
Novelty:  0.09327102
p_int:  0.999999473
p_ni:  5.27e-7
Data Source:  BioPlex
PTP4A2
Tchem
Family:  Enzyme
Novelty:  0.0083639
p_int:  0.999999203
p_ni:  7.91e-7
p_wrong:  5e-9
Score:  0.789
Data Source:  BioPlex,STRINGDB
BTNL8
Tdark
Novelty:  0.40339869
p_int:  0.999515998
p_ni:  0.000483758
p_wrong:  2.44e-7
Score:  0.15
Data Source:  BioPlex,STRINGDB
FCER1A
Tbio
Novelty:  0.00362182
p_int:  0.999281826
p_ni:  0.000718172
p_wrong:  2e-9
Data Source:  BioPlex
FDFT1
Tchem
Family:  Enzyme
Novelty:  0.00225882
p_int:  0.999022393
p_ni:  0.00097411
p_wrong:  0.000003497
Score:  0.174
Data Source:  BioPlex,STRINGDB
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.998714938
p_ni:  0.001285059
p_wrong:  3e-9
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.998419358
p_ni:  0.001580628
p_wrong:  1.3e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
P01911
Tchem
Novelty:  0.00240724
p_int:  0.997755524
p_ni:  0.002244459
p_wrong:  1.6e-8
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.996582265
p_ni:  0.00305691
p_wrong:  0.000360825
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
2
2
88.6
monocyte percentage of leukocytes
1
1
1
7.5
platelet crit
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
88.6
monocyte percentage of leukocytes
1
7.5
platelet crit
1
2.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin and CBS domain divalent metal cation transport mediator 1
VGNC:12285
466178
Mouse
MGI:1891366
83674
Rat
RGD:1308728
309387
Dog
cyclin and CBS domain divalent metal cation transport mediator 1
VGNC:39406
486833
Horse
cyclin and CBS domain divalent metal cation transport mediator 1
VGNC:50661
100070574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin and CBS domain divalent metal cation transport mediator 1
Mouse
Rat
Dog
cyclin and CBS domain divalent metal cation transport mediator 1
Horse
cyclin and CBS domain divalent metal cation transport mediator 1
Publication Statistics
PubMed Score 8.52
PubMed score by year
PubTator Score 3.78
PubTator score by year
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Related Publications
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PMID
Year
Title