Tdark CNNM1 Metal transporter CNNM1

Protein Summary

Description

Probable metal transporter. This gene encodes a member of the ancient conserved domain protein family. The encoded protein may bind copper. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q9NRU3
• Q4QQG7
• Q4QQH8
• Q4QQP9
• Q9NT45

Gene Name

• CNNM1

Ensembl ID

• ENST00000356713
• ENSP00000349147
• ENSG00000119946

Symbol

• ACDP1
• ACDP1
• CLP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.81
microRNA	0.81
phenotype	0.66
PubMedID	0.62
small molecule perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.52   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (85)

Explore Interacting Targets

1 – 10 of 85

• See Interactions on String-DB

PTP4A1

Tchem

Family:  Enzyme

Novelty:  0.02863007

p_int:  0.999999649

p_ni:  3.51e-7

Score:  0.791

Data Source:  BioPlex,STRINGDB

ARL15

Tbio

Family:  Enzyme

Novelty:  0.09327102

p_int:  0.999999473

p_ni:  5.27e-7

Data Source:  BioPlex

PTP4A2

Tchem

Family:  Enzyme

Novelty:  0.0083639

p_int:  0.999999203

p_ni:  7.91e-7

p_wrong:  5e-9

Score:  0.789

Data Source:  BioPlex,STRINGDB

BTNL8

Tdark

Novelty:  0.40339869

p_int:  0.999515998

p_ni:  0.000483758

p_wrong:  2.44e-7

Score:  0.15

Data Source:  BioPlex,STRINGDB

FCER1A

Tbio

Novelty:  0.00362182

p_int:  0.999281826

p_ni:  0.000718172

p_wrong:  2e-9

Data Source:  BioPlex

FDFT1

Tchem

Family:  Enzyme

Novelty:  0.00225882

p_int:  0.999022393

p_ni:  0.00097411

p_wrong:  0.000003497

Score:  0.174

Data Source:  BioPlex,STRINGDB

ASIC4

Tbio

Family:  IC

Novelty:  0.02912816

p_int:  0.998714938

p_ni:  0.001285059

p_wrong:  3e-9

Data Source:  BioPlex

PTCH1

Tbio

Novelty:  0.00077635

p_int:  0.998419358

p_ni:  0.001580628

p_wrong:  1.3e-8

Score:  0.169

Data Source:  BioPlex,STRINGDB

P01911

Tchem

Novelty:  0.00240724

p_int:  0.997755524

p_ni:  0.002244459

p_wrong:  1.6e-8

Data Source:  BioPlex

HFE

Tbio

Novelty:  0.00042077

p_int:  0.996582265

p_ni:  0.00305691

p_wrong:  0.000360825

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Components (4)

Processes (1)

Find Similar Targets

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
dendrite	Inferred from Electronic Annotation (IEA)	Ensembl
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
neuronal cell body	Inferred from Electronic Annotation (IEA)	Ensembl
plasma membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
aspartate aminotransferase measurement	EFO_0004736	2	2	2		88.6
monocyte percentage of leukocytes	EFO_0007989	1	1	1		7.5
platelet crit	EFO_0007985	1	1	1		2.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
aspartate aminotransferase measurement	EFO_0004736	2		88.6
monocyte percentage of leukocytes	EFO_0007989	1		7.5
platelet crit	EFO_0007985	1		2.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
CBS domain
Cell membrane
Complete proteome
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
aspartate aminotransferase measurement
monocyte percentage of leukocytes
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cyclin and CBS domain divalent metal cation transport mediator 1	VGNC:12285	466178
Mouse	cyclin M1	MGI:1891366	83674
Rat	cyclin and CBS domain divalent metal cation transport mediator 1	RGD:1308728	309387
Dog	cyclin and CBS domain divalent metal cation transport mediator 1	VGNC:39406	486833
Horse	cyclin and CBS domain divalent metal cation transport mediator 1	VGNC:50661	100070574

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cyclin and CBS domain divalent metal cation transport mediator 1
Mouse	cyclin M1
Rat	cyclin and CBS domain divalent metal cation transport mediator 1
Dog	cyclin and CBS domain divalent metal cation transport mediator 1
Horse	cyclin and CBS domain divalent metal cation transport mediator 1

Publication Statistics

PubMed Score 8.52

PubMed score by year

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PubTator Score 3.78

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (2)

Items per page:

10

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PMID	Year	Title