Protein Summary
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
- ENST00000252456
- ENSP00000252456
- ENSG00000130176
- SMCC
- Sm-Calp
- HEL-S-14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.93 | ||
gene perturbation | 0.85 | ||
kinase perturbation | 0.71 | ||
small molecule perturbation | 0.67 | ||
hub protein | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 176.57 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 957 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 176.57 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 957 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0