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Tbio
CNKSR3
Connector enhancer of kinase suppressor of ras 3

Protein Summary
Description
Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000607772
  • ENSP00000475915
  • ENSG00000153721

Symbol
  • MAGI1
  • CNK3
  • MAGI1
  • CNK3/IPCEF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.77
PubMedID
0.68
transcription factor perturbation
0.68
histone modification site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.15   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.15   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
SAMD10
Tdark
Novelty:  2.02197004
p_int:  0.999999996
p_ni:  4e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
ARHGAP39
Tbio
Family:  Enzyme
Novelty:  0.19918269
p_int:  0.999999995
p_ni:  5e-9
Score:  0.451
Data Source:  BioPlex,STRINGDB
VCPIP1
Tbio
Novelty:  0.09915033
p_int:  0.999999424
p_ni:  5.59e-7
p_wrong:  1.7e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.999998885
p_ni:  0.000001112
p_wrong:  3e-9
Data Source:  BioPlex
DIP2B
Tdark
Novelty:  0.14642544
p_int:  0.999985152
p_ni:  0.000014848
Score:  0.826
Data Source:  BioPlex,STRINGDB
PLOD3
Tbio
Family:  Enzyme
Novelty:  0.02211629
p_int:  0.999588283
p_ni:  0.000247199
p_wrong:  0.000164518
Data Source:  BioPlex
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.998968928
p_ni:  0.000137981
p_wrong:  0.00089309
Score:  0.319
Data Source:  BioPlex,STRINGDB
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
p_int:  0.997476129
p_ni:  0.002523871
Data Source:  BioPlex
NISCH
Tclin
Novelty:  0.00137246
p_int:  0.881926924
p_ni:  0.118073076
Score:  0.679
Data Source:  BioPlex,STRINGDB
MFSD4B
Tdark
Novelty:  0.03380333
Score:  0.628
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
67.5
lipoprotein A measurement
1
1
1
9.5
glomerular filtration rate
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
67.5
lipoprotein A measurement
1
9.5
glomerular filtration rate
1
6.6
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2674130
215748
Rat
RGD:1307544
308113
Cow
CNKSR family member 3
VGNC:27506
506781
Pig
CNKSR family member 3
100513248
Opossum
CNKSR family member 3
100032259
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
CNKSR family member 3
Pig
CNKSR family member 3
Opossum
CNKSR family member 3
Publication Statistics
PubMed Score 9.15
PubMed score by year
PubTator Score 6.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title