CNKSR2
Connector enhancer of kinase suppressor of ras 2
Protein Summary
May function as an adapter protein or regulator of Ras signaling pathways. This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
- ENST00000379510
- ENSP00000368824
- ENSG00000149970
- ENST00000425654
- ENSP00000397906
- ENST00000543067
- ENSP00000444633
- ENST00000642359
- ENSP00000496709
- CNK2
- KIAA0902
- KSR2
- CNK2
- KSR2
- MAGUIN
- MRXSHG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
microRNA | 0.88 | ||
cell type or tissue | 0.68 | ||
cellular component | 0.6 | ||
cell line | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.91 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 101 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.91 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 101 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0