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Tbio
CNKSR2
Connector enhancer of kinase suppressor of ras 2

Protein Summary
Description
May function as an adapter protein or regulator of Ras signaling pathways. This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379510
  • ENSP00000368824
  • ENSG00000149970
  • ENST00000425654
  • ENSP00000397906
  • ENST00000543067
  • ENSP00000444633
  • ENST00000642359
  • ENSP00000496709

Symbol
  • CNK2
  • KIAA0902
  • KSR2
  • CNK2
  • KSR2
  • MAGUIN
  • MRXSHG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
microRNA
0.88
cell type or tissue
0.68
cellular component
0.6
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.91   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.91   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
KSR1
Tbio
Family:  Kinase
Novelty:  0.00691155
Score:  0.994
Data Source:  STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.986
Data Source:  STRINGDB
KSR2
Tbio
Family:  Kinase
Novelty:  0.0473668
Score:  0.981
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.955
Data Source:  STRINGDB
ARAF
Tchem
Family:  Kinase
Novelty:  0.00432488
Score:  0.949
Data Source:  STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
Score:  0.948
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.942
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.94
Data Source:  STRINGDB
MAP2K2
Tclin
Family:  Kinase
Novelty:  0.00706525
Score:  0.921
Data Source:  STRINGDB
MAP2K1
Tclin
Family:  Kinase
Novelty:  0.0005278
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
85.8
schizophrenia
3
2
0
1.1
76.9
childhood trauma measurement
1
1
1
52.3
type 2 diabetes mellitus
2
1
1
1
43
insomnia measurement
1
1
0
1.1
19.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
85.8
schizophrenia
0
1.1
76.9
childhood trauma measurement
1
52.3
type 2 diabetes mellitus
1
1
43
insomnia measurement
0
1.1
19.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
connector enhancer of kinase suppressor of Ras 2
VGNC:1398
465531
Macaque
connector enhancer of kinase suppressor of Ras 2
696046
Mouse
MGI:2661175
245684
Rat
RGD:708454
59322
Dog
connector enhancer of kinase suppressor of Ras 2
VGNC:39404
480860
Species
Name
OMA
EggNOG
Inparanoid
Chimp
connector enhancer of kinase suppressor of Ras 2
Macaque
connector enhancer of kinase suppressor of Ras 2
Mouse
Rat
Dog
connector enhancer of kinase suppressor of Ras 2
Publication Statistics
PubMed Score 27.91
PubMed score by year
PubTator Score 13.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title