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Tchem
CNKSR1
Connector enhancer of kinase suppressor of ras 1

Protein Summary
Description
May function as an adapter protein or regulator of Ras signaling pathways. This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361530
  • ENSP00000354609
  • ENSG00000142675
  • ENST00000374253
  • ENSP00000363371

Symbol
  • CNK1
  • CNK
  • CNK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
gene perturbation
0.74
co-expressed gene
0.69
cell type or tissue
0.66
small molecule perturbation
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.23   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.23   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (87)
CYTH2
Tbio
Novelty:  0.03560664
p_int:  0.999999999
Score:  0.364
Data Source:  BioPlex,STRINGDB
CYTH1
Tbio
Novelty:  0.00635156
p_int:  0.999999976
p_ni:  5e-9
p_wrong:  1.9e-8
Score:  0.346
Data Source:  BioPlex,STRINGDB
CYTH3
Tbio
Novelty:  0.00940752
p_int:  0.999999975
p_ni:  2.3e-8
p_wrong:  2e-9
Score:  0.544
Data Source:  BioPlex,STRINGDB
HAUS5
Tbio
Novelty:  0.99720546
p_int:  0.983351501
p_ni:  0.016648499
Score:  0.188
Data Source:  BioPlex,STRINGDB
ASPM
Tbio
Novelty:  0.00599688
p_int:  0.948342178
p_ni:  0.051657822
Data Source:  BioPlex
PHLDB3
Tdark
Novelty:  2.01921901
p_int:  0.925486799
p_ni:  0.074513201
Score:  0.165
Data Source:  BioPlex,STRINGDB
TRIM24
Tchem
Family:  Epigenetic
Novelty:  0.00532747
p_int:  0.90226697
p_ni:  0.09773303
Score:  0.914
Data Source:  BioPlex,STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
p_int:  0.79322944
p_ni:  0.20677056
Score:  0.175
Data Source:  BioPlex,STRINGDB
TRIM33
Tchem
Family:  Epigenetic
Novelty:  0.00415877
p_int:  0.783275919
p_ni:  0.216724081
Data Source:  BioPlex
KSR1
Tbio
Family:  Kinase
Novelty:  0.00691155
Score:  0.989
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
65.5
eosinophil percentage of leukocytes
1
1
1
54.4
granulocyte percentage of myeloid white cells
1
1
1
49.5
BMI-adjusted waist-hip ratio
1
1
1
35
platelet crit
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.5
eosinophil percentage of leukocytes
1
54.4
granulocyte percentage of myeloid white cells
1
49.5
BMI-adjusted waist-hip ratio
1
35
platelet crit
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
connector enhancer of kinase suppressor of Ras 1
714154
Mouse
MGI:2670958
194231
Rat
RGD:1311879
298545
Dog
connector enhancer of kinase suppressor of Ras 1
VGNC:39403
100855977
Horse
connector enhancer of kinase suppressor of Ras 1
VGNC:16668
100071178
Species
Name
OMA
EggNOG
Inparanoid
Macaque
connector enhancer of kinase suppressor of Ras 1
Mouse
Rat
Dog
connector enhancer of kinase suppressor of Ras 1
Horse
connector enhancer of kinase suppressor of Ras 1
Publication Statistics
PubMed Score 20.23
PubMed score by year
PubTator Score 19.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title