Tbio CNIH2 Protein cornichon homolog 2

Protein Summary

Description

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q6PI25
• CNIH-2

Gene Name

• CNIH2

Ensembl ID

• ENST00000311445
• ENSP00000310003
• ENSG00000174871

Symbol

• CNIL
• Cnil
• CNIH-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.61
tissue sample	0.54
transcription factor	0.54
cell line	0.46
virus perturbation	0.45

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Protein Cornichon Homolog 2

Protein / Membrane Traffic Protein / Protein Cornichon Homolog 2

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Protein Cornichon Homolog 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.92   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.92   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0