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Tchem
CNGA3
Cyclic nucleotide-gated cation channel alpha-3

Protein Summary
Description
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272602
  • ENSP00000272602
  • ENSG00000144191
  • ENST00000393504
  • ENSP00000377140
  • ENST00000409937
  • ENSP00000386761
  • ENST00000436404
  • ENSP00000410070

Symbol
  • CNCG3
  • CNG3
  • ACHM2
  • CCNC1
  • CCNCa
  • CNCG3
  • CCNCalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cellular component
0.85
protein domain
0.73
transcription factor
0.57
biological process
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.51   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.51   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (102)
ACBD5
Tbio
Novelty:  0.10433432
p_int:  0.999999987
p_ni:  1e-9
p_wrong:  1.2e-8
Score:  0.272
Data Source:  BioPlex,STRINGDB
VPS52
Tbio
Novelty:  0.01439614
p_int:  0.999876054
p_ni:  0.000123946
Data Source:  BioPlex
SEMG2
Tbio
Novelty:  0.06325799
p_int:  0.999649417
p_ni:  0.000350583
Data Source:  BioPlex
C1orf43
Tbio
Novelty:  0.13587458
p_int:  0.99903629
p_ni:  0.000963708
p_wrong:  2e-9
Data Source:  BioPlex
ABCB9
Tbio
Family:  Transporter
Novelty:  0.02217672
p_int:  0.998740651
p_ni:  0.001259318
p_wrong:  3.1e-8
Data Source:  BioPlex
SEMG1
Tbio
Novelty:  0.0161449
p_int:  0.998278071
p_ni:  0.001721928
Data Source:  BioPlex
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.997607927
p_ni:  0.002392073
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.997284761
p_ni:  0.002715239
p_wrong:  1e-9
Data Source:  BioPlex
ADCY3
Tbio
Family:  Enzyme
Novelty:  0.00260265
p_int:  0.996491387
p_ni:  0.003484416
p_wrong:  0.000024198
Score:  0.376
Data Source:  BioPlex,STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.994998749
p_ni:  0.005001211
p_wrong:  3.9e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
9.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel alpha 3
VGNC:202
470517
Macaque
cyclic nucleotide gated channel alpha 3
707872
Mouse
MGI:1341818
12790
Rat
RGD:70948
85257
Horse
cyclic nucleotide gated channel alpha 3
VGNC:51294
100061333
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel alpha 3
Macaque
cyclic nucleotide gated channel alpha 3
Mouse
Rat
Horse
cyclic nucleotide gated channel alpha 3
Publication Statistics
PubMed Score 144.51
PubMed score by year
PubTator Score 75.73
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title