CNGA3
Cyclic nucleotide-gated cation channel alpha-3
Protein Summary
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000272602
- ENSP00000272602
- ENSG00000144191
- ENST00000393504
- ENSP00000377140
- ENST00000409937
- ENSP00000386761
- ENST00000436404
- ENSP00000410070
- CNCG3
- CNG3
- ACHM2
- CCNC1
- CCNCa
- CNCG3
- CCNCalpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
cellular component | 0.85 | ||
protein domain | 0.73 | ||
transcription factor | 0.57 | ||
biological process | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 144.51 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 108 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 144.51 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 108 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (102)
ACBD5
Novelty: 0.10433432
p_int: 0.999999987
p_ni: 1e-9
p_wrong: 1.2e-8
Score: 0.272
Data Source: BioPlex,STRINGDB
C1orf43
Novelty: 0.13587458
p_int: 0.99903629
p_ni: 0.000963708
p_wrong: 2e-9
Data Source: BioPlex
ABCB9
Family: Transporter
Novelty: 0.02217672
p_int: 0.998740651
p_ni: 0.001259318
p_wrong: 3.1e-8
Data Source: BioPlex
ATP2A3
Family: Transporter
Novelty: 0.0090982
p_int: 0.997284761
p_ni: 0.002715239
p_wrong: 1e-9
Data Source: BioPlex
ADCY3
Family: Enzyme
Novelty: 0.00260265
p_int: 0.996491387
p_ni: 0.003484416
p_wrong: 0.000024198
Score: 0.376
Data Source: BioPlex,STRINGDB
RAB6B
Family: Enzyme
Novelty: 0.0865097
p_int: 0.994998749
p_ni: 0.005001211
p_wrong: 3.9e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
KEGG (2)
PathwayCommons (2)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | cAMP signaling pathway | ||||
KEGG | Olfactory transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
cAMP signaling pathway | ||||
Olfactory transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (5)
Components (7)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 9.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 9.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cyclic nucleotide gated channel alpha 3 | VGNC:202 | 470517 | |||||
Macaque | cyclic nucleotide gated channel alpha 3 | 707872 | ||||||
Mouse | MGI:1341818 | 12790 | ||||||
Rat | RGD:70948 | 85257 | ||||||
Horse | cyclic nucleotide gated channel alpha 3 | VGNC:51294 | 100061333 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cyclic nucleotide gated channel alpha 3 | |||||
Macaque | cyclic nucleotide gated channel alpha 3 | |||||
Mouse | ||||||
Rat | ||||||
Horse | cyclic nucleotide gated channel alpha 3 | |||||
Publication Statistics
PubMed Score 144.51
PubMed score by year
PubTator Score 75.73
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (54)
GeneRif Annotations (41)
Items per page:
0 of 0
PMID | Year | Title |
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