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Tchem
CNGA1
cGMP-gated cation channel alpha-1

Protein Summary
Description
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358519
  • ENSP00000351320
  • ENSG00000198515
  • ENST00000402813
  • ENSP00000384264
  • ENST00000420489
  • ENSP00000389881
  • ENST00000514170
  • ENSP00000426862
  • ENST00000544810
  • ENSP00000443401

Symbol
  • CNCG
  • CNCG1
  • CNCG
  • CNG1
  • RP49
  • CNCG1
  • CNG-1
  • RCNC1
  • RCNCa
  • RCNCalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.73
gene perturbation
0.72
tissue sample
0.6
biological process
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.55   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.55   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (103)
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.983
Data Source:  Reactome,STRINGDB
PDE6A
Tclin
Family:  Enzyme
Novelty:  0.02680494
Score:  0.979
Data Source:  STRINGDB
PDE6B
Tclin
Family:  Enzyme
Novelty:  0.001105
Score:  0.976
Data Source:  STRINGDB
PDE6G
Tclin
Family:  Enzyme
Novelty:  0.03113994
Score:  0.969
Data Source:  STRINGDB
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.962
Data Source:  STRINGDB
GUCA1B
Tbio
Family:  Enzyme
Novelty:  0.02031715
Score:  0.957
Data Source:  STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.957
Data Source:  STRINGDB
GUCA1C
Tdark
Family:  Enzyme
Novelty:  0.25914047
Score:  0.923
Data Source:  STRINGDB
FAM161A
Tbio
Novelty:  0.066177
Score:  0.828
Data Source:  STRINGDB
CNGB3
Tchem
Family:  IC
Novelty:  0.01174942
Score:  0.794
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (36)
Activation of the phototransduction cascade (R-HSA-2485179)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
83
1
1
0
1.3
24.5
urate measurement
1
1
1
15.8
1
1
0
1.7
15.8
aspartate aminotransferase measurement
1
1
0
5.7
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
83
0
1.3
24.5
urate measurement
1
15.8
0
1.7
15.8
aspartate aminotransferase measurement
0
5.7
4.7
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel alpha 1
VGNC:10847
739850
Macaque
cyclic nucleotide gated channel alpha 1
704891
Mouse
MGI:88436
12788
Rat
RGD:621815
85259
Dog
cyclic nucleotide gated channel alpha 1
VGNC:39395
403891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel alpha 1
Macaque
cyclic nucleotide gated channel alpha 1
Mouse
Rat
Dog
cyclic nucleotide gated channel alpha 1
Publication Statistics
PubMed Score 141.55
PubMed score by year
PubTator Score 37.18
PubTator score by year
Patents
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Related Publications
Items per page:
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PMID
Year
Title