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Tbio
CNBP
Cellular nucleic acid-binding protein

Protein Summary
Description
Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression. This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422453
  • ENSP00000410619
  • ENSG00000169714
  • ENST00000441626
  • ENSP00000410769
  • ENST00000446936
  • ENSP00000400444
  • ENST00000451728
  • ENSP00000399488
  • ENST00000500450
  • ENSP00000426223
  • ENST00000502976
  • ENSP00000421323
  • ENST00000504813
  • ENSP00000422110

Symbol
  • RNF163
  • ZNF9
  • DM2
  • ZNF9
  • CNBP1
  • PROMM
  • RNF163
  • ZCCHC22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.99
interacting protein
0.96
virus perturbation
0.85
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.24   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.24   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
TRIM56
Tbio
Family:  Enzyme
Novelty:  0.09343452
p_int:  0.999999995
p_ni:  4e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999994251
p_ni:  0.000005748
p_wrong:  2e-9
Data Source:  BioPlex
NLE1
Tbio
Novelty:  0.03831535
p_int:  0.998989135
p_ni:  0.001010865
Score:  0.353
Data Source:  BioPlex,STRINGDB
ZNF275
Tdark
Family:  TF
Novelty:  3.7512462
p_int:  0.994989056
p_ni:  0.004603921
p_wrong:  0.000407023
Score:  0.199
Data Source:  BioPlex,STRINGDB
ITGB3BP
Tbio
Novelty:  0.06162186
p_int:  0.994225039
p_ni:  0.004935921
p_wrong:  0.000839041
Data Source:  BioPlex
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.992600334
p_ni:  0.007399666
Score:  0.451
Data Source:  BioPlex,STRINGDB
RPL36
Tbio
Novelty:  0.02259932
p_int:  0.991070935
p_ni:  0.008929065
Score:  0.303
Data Source:  BioPlex,STRINGDB
RPF2
Tbio
Novelty:  0.04148504
p_int:  0.990495563
p_ni:  0.009504437
Score:  0.363
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.989616948
p_ni:  0.010383052
Score:  0.195
Data Source:  BioPlex,STRINGDB
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.988763974
p_ni:  0.011236026
Score:  0.279
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
3
3
89.5
body height
1
1
1
75.2
BMI-adjusted waist-hip ratio
1
2
2
60.8
waist-hip ratio
1
2
2
57.1
hip circumference
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
89.5
body height
1
75.2
BMI-adjusted waist-hip ratio
2
60.8
waist-hip ratio
2
57.1
hip circumference
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCHC-type zinc finger nucleic acid binding protein
VGNC:9669
460682
Macaque
CCHC-type zinc finger nucleic acid binding protein
705622
Mouse
MGI:88431
12785
Rat
RGD:621807
64530
Dog
CCHC-type zinc finger nucleic acid binding protein
VGNC:39390
476518
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCHC-type zinc finger nucleic acid binding protein
Macaque
CCHC-type zinc finger nucleic acid binding protein
Mouse
Rat
Dog
CCHC-type zinc finger nucleic acid binding protein
Publication Statistics
PubMed Score 268.24
PubMed score by year
PubTator Score 257.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title