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Tbio
CMTR2
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338099
  • ENSP00000337512
  • ENSG00000180917
  • ENST00000434935
  • ENSP00000411148

Symbol
  • AFT
  • FTSJD1
  • AFT
  • MTr2
  • HMTr2
  • FTSJD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.68
kinase perturbation
0.6
transcription factor binding site profile
0.59
tissue sample
0.52
cell line
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999999864
p_ni:  1.36e-7
Data Source:  BioPlex
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999999802
p_ni:  1.92e-7
p_wrong:  7e-9
Score:  0.598
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.9999994
p_ni:  1.07e-7
p_wrong:  4.93e-7
Score:  0.622
Data Source:  BioPlex,STRINGDB
SNRPC
Tbio
Novelty:  0.02049921
p_int:  0.999999252
p_ni:  7.47e-7
p_wrong:  1e-9
Data Source:  BioPlex
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999998225
p_ni:  0.000001768
p_wrong:  7e-9
Score:  0.64
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999994232
p_ni:  0.000004072
p_wrong:  0.000001696
Score:  0.564
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999990637
p_ni:  2.31e-7
p_wrong:  0.000009132
Data Source:  BioPlex
CMTR1
Tbio
Family:  Enzyme
Novelty:  0.09259694
Score:  0.925
Data Source:  STRINGDB
TGS1
Tbio
Family:  Enzyme
Novelty:  0.03390504
Score:  0.719
Data Source:  STRINGDB
AFG1L
Tbio
Novelty:  0.0034716
Score:  0.702
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
WikiPathways
Pathways Affected in Adenoid Cystic Carcinoma
Name
Explore in Pharos
Explore in Source
Pathways Affected in Adenoid Cystic Carcinoma
Pathways Affected in Adenoid Cystic Carcinoma
Pathways Affected in Adenoid Cystic Carcinoma
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
42.3
risk-taking behaviour
1
1
1
4.2
neuroticism measurement
1
1
0
5.6
1
mood instability measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
42.3
risk-taking behaviour
1
4.2
neuroticism measurement
0
5.6
1
mood instability measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cap methyltransferase 2
711529
Mouse
MGI:2384580
234728
Rat
RGD:1309394
292016
Dog
cap methyltransferase 2
VGNC:39386
489718
Horse
cap methyltransferase 2
VGNC:16656
100068485
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cap methyltransferase 2
Mouse
Rat
Dog
cap methyltransferase 2
Horse
cap methyltransferase 2
Publication Statistics
PubMed Score 10.91
PubMed score by year
PubTator Score 13.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title