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Tbio
CMTR1
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373451
  • ENSP00000362550
  • ENSG00000137200

Symbol
  • FTSJD2
  • KIAA0082
  • MTR1
  • MTr1
  • hMTr1
  • FTSJD2
  • KIAA0082
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.82
cell type or tissue
0.78
histone modification site profile
0.77
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
SPATA1
Tdark
p_int:  0.998415698
p_ni:  0.001584302
Data Source:  BioPlex
WASF3
Tbio
Novelty:  0.0248378
p_int:  0.990119422
p_ni:  0.009880578
Score:  0.205
Data Source:  BioPlex,STRINGDB
TMCC2
Tdark
Novelty:  0.21581357
p_int:  0.960707793
p_ni:  0.039292207
Score:  0.219
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.899692249
p_ni:  0.100307746
p_wrong:  5e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
RNMT
Tbio
Family:  Enzyme
Novelty:  0.00880207
Score:  0.958
Data Source:  STRINGDB
CMTR2
Tbio
Family:  Enzyme
Novelty:  0.11208282
Score:  0.925
Data Source:  STRINGDB
EXOSC2
Tbio
Novelty:  0.08163283
Score:  0.703
Data Source:  STRINGDB
BLVRB
Tbio
Family:  Enzyme
Novelty:  0.00705559
Score:  0.682
Data Source:  STRINGDB
ZCCHC2
Tdark
Novelty:  0.48236611
Score:  0.682
Data Source:  STRINGDB
RNF8
Tbio
Family:  Enzyme
Novelty:  0.01189548
Score:  0.598
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
77.6
self reported educational attainment
1
1
1
56
smoking behavior
1
1
1
40.7
smoking status measurement
1
1
1
40.7
smoking behaviour measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
77.6
self reported educational attainment
1
56
smoking behavior
1
40.7
smoking status measurement
1
40.7
smoking behaviour measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cap methyltransferase 1
VGNC:2676
471998
Macaque
cap methyltransferase 1
719402
Mouse
MGI:1921407
74157
Rat
RGD:1307801
309656
Dog
cap methyltransferase 1
VGNC:39385
100683999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cap methyltransferase 1
Macaque
cap methyltransferase 1
Mouse
Rat
Dog
cap methyltransferase 1
Publication Statistics
PubMed Score 13.72
PubMed score by year
PubTator Score 7.35
PubTator score by year
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Related Publications
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PMID
Year
Title