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Tbio
CMTM8
CKLF-like MARVEL transmembrane domain-containing protein 8

Protein Summary
Description
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307526
  • ENSP00000307741
  • ENSG00000170293
  • ENST00000458535
  • ENSP00000412934

Symbol
  • CKLFSF8
  • CKLFSF8
  • CKLFSF8-V2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
virus perturbation
0.85
histone modification site profile
0.84
PubMedID
0.7
transcription factor binding site profile
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
VMA21
Tdark
Family:  Enzyme
Novelty:  0.46129032
p_int:  0.999994578
p_ni:  0.000004736
p_wrong:  6.86e-7
Data Source:  BioPlex
POU2F1
Tbio
Family:  TF
Novelty:  0.00722164
p_int:  0.999720085
p_ni:  0.000110249
p_wrong:  0.000169667
Data Source:  BioPlex
TMEM242
Tdark
Novelty:  0.99055845
p_int:  0.999666414
p_ni:  0.000141457
p_wrong:  0.000192129
Data Source:  BioPlex
SLC25A24
Tbio
Family:  Transporter
Novelty:  0.06151955
p_int:  0.999617251
p_ni:  0.00038273
p_wrong:  1.9e-8
Data Source:  BioPlex
FAM210B
Tbio
Novelty:  0.19704434
p_int:  0.996284431
p_ni:  0.003492037
p_wrong:  0.000223533
Data Source:  BioPlex
ECPAS
Tbio
Novelty:  0.04004664
p_int:  0.995342534
p_ni:  0.004657466
Data Source:  BioPlex
HIP1R
Tbio
Novelty:  0.02502713
p_int:  0.993281669
p_ni:  0.006718085
p_wrong:  2.46e-7
Data Source:  BioPlex
ATP6AP2
Tbio
Novelty:  0.00357665
p_int:  0.993223028
p_ni:  0.006776511
p_wrong:  4.62e-7
Data Source:  BioPlex
SLC25A23
Tbio
Family:  Transporter
Novelty:  0.10446757
p_int:  0.991598855
p_ni:  0.002197379
p_wrong:  0.006203766
Data Source:  BioPlex
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
p_int:  0.989949118
p_ni:  0.010049798
p_wrong:  0.000001084
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgM measurement
1
1
1
62.1
body height
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgM measurement
1
62.1
body height
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CKLF like MARVEL transmembrane domain containing 8
VGNC:7037
460249
Macaque
CKLF like MARVEL transmembrane domain containing 8
704234
Mouse
MGI:2447167
70031
Rat
RGD:735040
301045
Dog
CKLF like MARVEL transmembrane domain containing 8
VGNC:39384
485625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CKLF like MARVEL transmembrane domain containing 8
Macaque
CKLF like MARVEL transmembrane domain containing 8
Mouse
Rat
Dog
CKLF like MARVEL transmembrane domain containing 8
Publication Statistics
PubMed Score 13.04
PubMed score by year
PubTator Score 10.18
PubTator score by year
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Related Publications
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PMID
Year
Title