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Tchem
CMPK1
UMP-CMP kinase

Protein Summary
Description
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371873
  • ENSP00000360939
  • ENSG00000162368
  • ENST00000450808
  • ENSP00000398192

Symbol
  • CMK
  • CMPK
  • UCK
  • UMK
  • UMPK
  • CK
  • CMK
  • UMK
  • CMPK
  • UMPK
  • UMP-CMPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
kinase perturbation
0.93
histone modification site profile
0.88
microRNA
0.87
biological process
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.99   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 415   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.99   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0