You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CMKLR1
Chemokine-like receptor 1

Protein Summary
Description
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312143
  • ENSP00000311733
  • ENSG00000174600
  • ENST00000412676
  • ENSP00000401293
  • ENST00000550402
  • ENSP00000449716
  • ENST00000552995
  • ENSP00000447579

Symbol
  • CHEMR23
  • DEZ
  • DEZ
  • RVER1
  • ChemR23
  • CHEMERINR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
biological process
0.64
tissue sample
0.61
cell line
0.6
PubMedID
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.75   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 537   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.75   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 537   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0