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Tbio
CMAS
N-acylneuraminate cytidylyltransferase

Protein Summary
Description
Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). This gene encodes an enzyme that converts N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc). This process is important in the formation of sialylated glycoprotein and glycolipids. This modification plays a role in cell-cell communications and immune responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229329
  • ENSP00000229329
  • ENSG00000111726
  • ENST00000534981
  • ENSP00000446239

Symbol
  • CSS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.88
disease perturbation
0.87
transcription factor binding site profile
0.79
PubMedID
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
RNASEH1
Tchem
Family:  Enzyme
Novelty:  0.01838314
p_int:  0.999573554
p_ni:  0.000426446
Data Source:  BioPlex
LIMS1
Tbio
Novelty:  0.00648304
p_int:  0.998900104
p_ni:  0.001099896
Score:  0.188
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.990518751
p_ni:  0.009481249
Data Source:  BioPlex
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.94876806
p_ni:  0.051231931
p_wrong:  8e-9
Score:  0.392
Data Source:  BioPlex,STRINGDB
DBNL
Tbio
Novelty:  0.03390948
p_int:  0.946444153
p_ni:  0.053555847
Score:  0.228
Data Source:  BioPlex,STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.870100857
p_ni:  0.129899143
Data Source:  BioPlex
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.797618686
p_ni:  0.202381314
Data Source:  BioPlex
FAM98A
Tdark
Novelty:  0.30067413
p_int:  0.760251488
p_ni:  0.239748512
Score:  0.189
Data Source:  BioPlex,STRINGDB
NANS
Tbio
Family:  Enzyme
Novelty:  0.00718044
Score:  0.996
Data Source:  STRINGDB
NANP
Tbio
Family:  Enzyme
Novelty:  0.01876342
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Sialic acid metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Sialic acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytidine monophosphate N-acetylneuraminic acid synthetase
VGNC:5341
465340
Macaque
cytidine monophosphate N-acetylneuraminic acid synthetase
706604
Mouse
MGI:1337124
12764
Rat
RGD:1310911
312826
Dog
cytidine monophosphate N-acetylneuraminic acid synthetase
VGNC:39375
477673
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytidine monophosphate N-acetylneuraminic acid synthetase
Macaque
cytidine monophosphate N-acetylneuraminic acid synthetase
Mouse
Rat
Dog
cytidine monophosphate N-acetylneuraminic acid synthetase
Publication Statistics
PubMed Score 22.02
PubMed score by year
PubTator Score 132.37
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title