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Tchem
CMA1
Chymase

Protein Summary
Description
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000206446
  • ENSP00000206446
  • ENSG00000092009
  • ENST00000250378
  • ENSP00000250378

Symbol
  • CYH
  • CYM
  • CYH
  • MCT1
  • chymase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.76
biological term
0.72
gene perturbation
0.67
co-expressed gene
0.65
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1138.31   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1138.31   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 370
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (370)
Protein-Protein Interactions (82)
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.999372229
p_ni:  0.000627771
Data Source:  BioPlex
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.998024282
p_ni:  0.001975715
p_wrong:  3e-9
Data Source:  BioPlex
FAT1
Tbio
Novelty:  0.00340342
p_int:  0.98300552
p_ni:  0.01699448
Data Source:  BioPlex
FREM2
Tbio
Novelty:  0.03382033
p_int:  0.979539825
p_ni:  0.020460175
Data Source:  BioPlex
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.978638946
p_ni:  0.021361054
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.977007467
p_ni:  0.022992533
Data Source:  BioPlex
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.968822684
p_ni:  0.031056489
p_wrong:  0.000120828
Data Source:  BioPlex
ITIH2
Tbio
Novelty:  0.04886358
p_int:  0.951415686
p_ni:  0.046914958
p_wrong:  0.001669357
Data Source:  BioPlex
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.9341222
p_ni:  0.0658778
Data Source:  BioPlex
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
p_int:  0.913668859
p_ni:  0.086331141
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (91)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
2
6
75.7
total cholesterol measurement
1
2
4
61.8
hemoglobin measurement
2
1
2
55.2
1
1
0
1.1
35
Ischemic stroke
1
1
0
3.3
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
6
75.7
total cholesterol measurement
4
61.8
hemoglobin measurement
2
55.2
0
1.1
35
Ischemic stroke
0
3.3
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chymase 1
VGNC:8197
745533
Macaque
chymase 1
716395
Mouse
MGI:96941
17228
Rat
RGD:2365
25627
Dog
chymase 1
VGNC:49768
490628
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chymase 1
Macaque
chymase 1
Mouse
Rat
Dog
chymase 1
Publication Statistics
PubMed Score 1138.31
PubMed score by year
PubTator Score 474.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title