Tbio CLVS2 Clavesin-2

Protein Summary

Description

Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). This gene encodes a protein that belongs to the SEC14/CRAL-TRIO family of proteins. A similar protein in rat is thought to function in the endosomal pathway between early endosomes and mature lysosomes. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q5SYC1
• B3KTG5
• B4DHL0
• C8UZT4
• Q5SYC0

Gene Name

• CLVS2

Ensembl ID

• ENST00000275162
• ENSP00000275162
• ENSG00000146352
• ENST00000368438
• ENSP00000357423

Symbol

• C6orf212
• C6orf213
• RLBP1L2
• RLBP1L2
• C6orf212
• C6orf213
• bA160A10.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
cellular component	0.52
histone modification site profile	0.52
cell type or tissue	0.46
cell line	0.44

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Clavesin-2

DTO Classes

Protein / Transporter / Clavesin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0