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Tbio
CLUH
Clustered mitochondria protein homolog

Protein Summary
Description
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435359
  • ENSP00000388872
  • ENSG00000132361
  • ENST00000570628
  • ENSP00000458986

Symbol
  • KIAA0664
  • CLU1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
protein domain
0.73
drug perturbation
0.71
transcription factor
0.71
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.33   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.33   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
CLPB
Tbio
Family:  Enzyme
Novelty:  0.00209789
p_int:  0.999995636
p_ni:  0.000004364
Score:  0.218
Data Source:  BioPlex,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.999820633
p_ni:  0.000179367
Data Source:  BioPlex
DCAF4L2
Tdark
Novelty:  0.55635961
p_int:  0.999801499
p_ni:  0.000198501
p_wrong:  1e-9
Score:  0.233
Data Source:  BioPlex,STRINGDB
TEKT3
Tbio
Novelty:  0.06646482
p_int:  0.998287003
p_ni:  0.001712997
Score:  0.159
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.997547853
p_ni:  0.002452146
Data Source:  BioPlex
WDR37
Tbio
Novelty:  0.1677975
p_int:  0.996747686
p_ni:  0.003252314
Score:  0.185
Data Source:  BioPlex,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.996698548
p_ni:  0.003301452
Score:  0.158
Data Source:  BioPlex,STRINGDB
ZAR1L
Tdark
Novelty:  0.08793345
p_int:  0.995851626
p_ni:  0.004148374
Data Source:  BioPlex
WDR90
Tdark
Novelty:  0.39919716
p_int:  0.995659743
p_ni:  0.004340255
p_wrong:  2e-9
Score:  0.248
Data Source:  BioPlex,STRINGDB
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
p_int:  0.982209538
p_ni:  0.017790462
Score:  0.438
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Translation Factors
WikiPathways
Translation Factors
WikiPathways
Photodynamic therapy-induced unfolded protein response
WikiPathways
VEGFA-VEGFR2 Signaling Pathway
WikiPathways
Nonalcoholic fatty liver disease
Name
Explore in Pharos
Explore in Source
Translation Factors
Translation Factors
Photodynamic therapy-induced unfolded protein response
VEGFA-VEGFR2 Signaling Pathway
Nonalcoholic fatty liver disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
6
3
6
71.4
wellbeing measurement
2
3
3
64.3
mean platelet volume
2
2
2
63
alkaline phosphatase measurement
1
1
1
59.8
depressive symptom measurement
1
2
2
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
6
71.4
wellbeing measurement
3
64.3
mean platelet volume
2
63
alkaline phosphatase measurement
1
59.8
depressive symptom measurement
2
58.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
clustered mitochondria homolog
VGNC:49001
454423
Macaque
clustered mitochondria homolog
704219
Mouse
MGI:1921398
74148
Rat
RGD:1307222
303300
Dog
clustered mitochondria homolog
491203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
clustered mitochondria homolog
Macaque
clustered mitochondria homolog
Mouse
Rat
Dog
clustered mitochondria homolog
Publication Statistics
PubMed Score 9.33
PubMed score by year
PubTator Score 9.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title