Protein Summary
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional ...more
- ENST00000316403
- ENSP00000315130
- ENSG00000120885
- ENST00000405140
- ENSP00000385419
- ENST00000523500
- ENSP00000429620
- APOJ
- CLI
- KUB1
- CLI
- AAG4
- APOJ
- CLU1
- CLU2
- KUB1
- SGP2
- APO-J
- SGP-2
- SP-40
- TRPM2
- TRPM-2
- NA1/NA2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 0.96 | ||
PubMedID | 0.95 | ||
chemical | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2031.24 (req: < 5)
Gene RIFs: 385 (req: <= 3)
Antibodies: 1092 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2031.24 (req: >= 5)
Gene RIFs: 385 (req: > 3)
Antibodies: 1092 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 57
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (321)
SDK2
Novelty: 0.08867136
p_int: 0.999979449
p_ni: 0.000020551
Score: 0.202
Data Source: BioPlex,STRINGDB
ATP2B2
Family: Transporter
Novelty: 0.007782
p_int: 0.999913591
p_ni: 0.000086409
Score: 0.204
Data Source: BioPlex,STRINGDB
PTPRS
Family: Enzyme
Novelty: 0.00587115
p_int: 0.999888761
p_ni: 0.000111239
Score: 0.17
Data Source: BioPlex,STRINGDB
TENM3
Novelty: 0.0251948
p_int: 0.999738844
p_ni: 0.000261155
p_wrong: 1e-9
Score: 0.359
Data Source: BioPlex,STRINGDB
FBXO27
Novelty: 0.27910336
p_int: 0.999641451
p_ni: 0.000008264
p_wrong: 0.000350285
Score: 0.187
Data Source: BioPlex,STRINGDB
CBWD3
Novelty: 0.03639787
p_int: 0.99948875
p_ni: 0.000511242
p_wrong: 9e-9
Data Source: BioPlex
KIAA0355
Novelty: 0.97113831
p_int: 0.999447195
p_ni: 0.000552805
Score: 0.185
Data Source: BioPlex,STRINGDB
DHX57
Family: Enzyme
Novelty: 0.8244078
p_int: 0.998109936
p_ni: 0.001890064
Data Source: BioPlex
ITGA8
Novelty: 0.0220023
p_int: 0.997451574
p_ni: 0.00254841
p_wrong: 1.6e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (20)
Reactome (10)
KEGG (1)
PathwayCommons (2)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Complement cascade | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antimicrobial peptides | ||||
Complement cascade | ||||
Hemostasis | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (79)
Functions (8)
Components (22)
Processes (49)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ARUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | ParkinsonsUK-UCL | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Disease Associations (null)
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 2 | 3 | 93.4 | |||||
smoking initiation | 3 | 3 | 3 | 93 | |||||
6 | 3 | 0 | 4.8 | 89.5 | |||||
family history of Alzheimer’s disease | 1 | 2 | 0 | 8.7 | 83.2 | ||||
cigarettes per day measurement | 3 | 3 | 4 | 75.2 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
smoking status measurement | 3 | 93.4 | |||||
smoking initiation | 3 | 93 | |||||
0 | 4.8 | 89.5 | |||||
family history of Alzheimer’s disease | 0 | 8.7 | 83.2 | ||||
cigarettes per day measurement | 4 | 75.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | clusterin | VGNC:908 | 464075 | |||||
Macaque | clusterin | 677866 | ||||||
Mouse | MGI:88423 | 12759 | ||||||
Rat | RGD:3907 | 24854 | ||||||
Dog | clusterin | VGNC:39369 | 442971 | |||||
Publication Statistics
PubMed Score 2031.24
PubMed score by year
PubTator Score 901.05
PubTator score by year
Related Publications
Text Mined References (472)
GeneRif Annotations (385)
Items per page:
0 of 0
PMID | Year | Title |
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