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Tbio
CLU
Clusterin

Protein Summary
Description
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316403
  • ENSP00000315130
  • ENSG00000120885
  • ENST00000405140
  • ENSP00000385419
  • ENST00000523500
  • ENSP00000429620

Symbol
  • APOJ
  • CLI
  • KUB1
  • CLI
  • AAG4
  • APOJ
  • CLU1
  • CLU2
  • KUB1
  • SGP2
  • APO-J
  • SGP-2
  • SP-40
  • TRPM2
  • TRPM-2
  • NA1/NA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
1
virus perturbation
0.96
PubMedID
0.95
chemical
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2218.06   (req: < 5)
Gene RIFs: 385   (req: <= 3)
Antibodies: 1092   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2218.06   (req: >= 5)
Gene RIFs: 385   (req: > 3)
Antibodies: 1092   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0