Protein Summary
May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.
- ENST00000266546
- ENSP00000266546
- ENSG00000139182
- CS3
- KIAA0726
- CSTN3
- CDHR14
- alcbeta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.82 | ||
histone modification site profile | 0.79 | ||
cellular component | 0.76 | ||
transcription factor | 0.72 | ||
cell line | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.79 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 26 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.79 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 26 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0