Protein Summary
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity). This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transp ...more
- ENST00000361311
- ENSP00000354997
- ENSG00000171603
- ENST00000377298
- ENSP00000366513
- CS1
- KIAA0911
- CST-1
- CSTN1
- CDHR12
- PIK3CD
- ALC-ALPHA
- XB31alpha
- alcalpha1
- alcalpha2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
virus perturbation | 0.92 | ||
microRNA | 0.74 | ||
transcription factor binding site profile | 0.73 | ||
cellular component | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.3 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 165 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 32.3 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 165 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (58)
APBA3
Novelty: 0.05059532
p_int: 0.93351499
p_ni: 0.06648501
Score: 0.162
Data Source: BioPlex,STRINGDB
PVRIG
Novelty: 0.28920924
p_int: 0.926823103
p_ni: 0.073176897
Score: 0.203
Data Source: BioPlex,STRINGDB
PCDHA4
Novelty: 0.30511211
p_int: 0.917131507
p_ni: 0.082868493
Score: 0.163
Data Source: BioPlex,STRINGDB
CDCP1
Novelty: 0.01385067
p_int: 0.906232639
p_ni: 0.093767361
Score: 0.34
Data Source: BioPlex,STRINGDB
LYPD5
Novelty: 0.97576337
p_int: 0.895913492
p_ni: 0.104086508
Score: 0.252
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Splicing factor NOVA regulated synaptic proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Splicing factor NOVA regulated synaptic proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (4)
Components (12)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 83 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 71.6 | |||||
1 | 1 | 0 | 1.1 | 56.6 | |||||
monocyte count | 2 | 1 | 2 | 45.1 | |||||
lymphocyte count | 1 | 1 | 1 | 5.2 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 83 | |||||
eosinophil percentage of leukocytes | 1 | 71.6 | |||||
0 | 1.1 | 56.6 | |||||
monocyte count | 2 | 45.1 | |||||
lymphocyte count | 1 | 5.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | calsyntenin 1 | VGNC:504 | 100611252 | |||||
Macaque | calsyntenin 1 [Source:HGNC Symbol;Acc:HGNC:17447] | |||||||
Mouse | MGI:1929895 | 65945 | ||||||
Rat | RGD:1306458 | 313717 | ||||||
Dog | calsyntenin 1 [Source:HGNC Symbol;Acc:HGNC:17447] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | calsyntenin 1 | |||||
Macaque | calsyntenin 1 [Source:HGNC Symbol;Acc:HGNC:17447] | |||||
Mouse | ||||||
Rat | ||||||
Dog | calsyntenin 1 [Source:HGNC Symbol;Acc:HGNC:17447] | |||||
Publication Statistics
PubMed Score 32.30
PubMed score by year
PubTator Score 12.62
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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