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Tbio
CLPTM1
Cleft lip and palate transmembrane protein 1

Protein Summary
Description
May play a role in T-cell development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337392
  • ENSP00000336994
  • ENSG00000104853
  • ENST00000541297
  • ENSP00000442011
  • ENST00000546079
  • ENSP00000443192
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
transcription factor binding site profile
0.74
transcription factor
0.66
cell type or tissue
0.65
cell line
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.87   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.87   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.995432518
p_ni:  0.004567482
Score:  0.186
Data Source:  BioPlex,STRINGDB
SRD5A2
Tclin
Family:  Enzyme
Novelty:  0.00281044
p_int:  0.994167419
p_ni:  0.005832581
Data Source:  BioPlex
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.992808716
p_ni:  0.007191284
Score:  0.224
Data Source:  BioPlex,STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
p_int:  0.956248769
p_ni:  0.043751231
Score:  0.218
Data Source:  BioPlex,STRINGDB
GPR108
Tbio
Novelty:  0.24228136
p_int:  0.95181335
p_ni:  0.04818665
Data Source:  BioPlex
KLRC4
Tbio
Novelty:  0.16922525
p_int:  0.894029996
p_ni:  0.105970004
Data Source:  BioPlex
ODF4
Tbio
Novelty:  0.13423621
p_int:  0.812377259
p_ni:  0.187622741
Score:  0.282
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.764887299
p_ni:  0.235112701
Data Source:  BioPlex
NKPD1
Tdark
Family:  Enzyme
Novelty:  0.77385086
Score:  0.732
Data Source:  STRINGDB
SYNJ2
Tchem
Novelty:  0.03679911
Score:  0.727
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (118)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
34
71
108
8
100
apolipoprotein B measurement
2
62
63
100
total cholesterol measurement
21
60
88
6.8
100
C-reactive protein measurement
14
56
72
21.8
100
26
59
2
2.9
99.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
108
8
100
apolipoprotein B measurement
63
100
total cholesterol measurement
88
6.8
100
C-reactive protein measurement
72
21.8
100
2
2.9
99.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CLPTM1, transmembrane protein
VGNC:10378
468914
Macaque
CLPTM1, transmembrane protein
718306
Mouse
MGI:1927155
56457
Rat
RGD:1310959
292696
Dog
CLPTM1, transmembrane protein
VGNC:39357
484455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CLPTM1, transmembrane protein
Macaque
CLPTM1, transmembrane protein
Mouse
Rat
Dog
CLPTM1, transmembrane protein
Publication Statistics
PubMed Score 10.87
PubMed score by year
PubTator Score 10.04
PubTator score by year
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Related Publications
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PMID
Year
Title