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Tchem
CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

Protein Summary
Description
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245816
  • ENSP00000245816
  • ENSG00000125656

Symbol
  • DFNB81
  • PRLTS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.97
interacting protein
0.83
transcription factor binding site profile
0.79
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1022.86   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1022.86   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (228)
RCC1L
Tbio
Novelty:  0.03545003
p_int:  0.998210575
p_ni:  0.001789425
Data Source:  BioPlex
FDPS
Tclin
Family:  Enzyme
Novelty:  0.00164195
p_int:  0.996503496
p_ni:  0.003496504
Score:  0.284
Data Source:  BioPlex,STRINGDB
PPA2
Tbio
Family:  Enzyme
Novelty:  0.01790138
p_int:  0.994062542
p_ni:  0.005937458
Score:  0.306
Data Source:  BioPlex,STRINGDB
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.97788451
p_ni:  0.02211549
Data Source:  BioPlex
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.974001604
p_ni:  0.025998391
p_wrong:  4e-9
Score:  0.409
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.96158432
p_ni:  0.038415671
p_wrong:  1e-8
Data Source:  BioPlex
ABCG2
Tchem
Family:  Transporter
Novelty:  0.00029779
p_int:  0.959667742
p_ni:  0.040332258
Data Source:  BioPlex
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.940174868
p_ni:  0.059822646
p_wrong:  0.000002485
Data Source:  BioPlex
MTG2
Tbio
Family:  Enzyme
Novelty:  0.06104792
p_int:  0.92766657
p_ni:  0.07233343
Score:  0.384
Data Source:  BioPlex,STRINGDB
FBXO17
Tbio
Novelty:  0.1320754
p_int:  0.920871613
p_ni:  0.079128387
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caseinolytic mitochondrial matrix peptidase proteolytic subunit
VGNC:2385
455637
Macaque
caseinolytic mitochondrial matrix peptidase proteolytic subunit
699593
Mouse
MGI:1858213
53895
Rat
RGD:1588583
301117
Dog
caseinolytic mitochondrial matrix peptidase proteolytic subunit
VGNC:39356
611738
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caseinolytic mitochondrial matrix peptidase proteolytic subunit
Macaque
caseinolytic mitochondrial matrix peptidase proteolytic subunit
Mouse
Rat
Dog
caseinolytic mitochondrial matrix peptidase proteolytic subunit
Publication Statistics
PubMed Score 1022.86
PubMed score by year
PubTator Score 151.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title